Neşe GÖÇER GÜROK

The Correlation between Melasma and ABO Blood Type

Aim: Melasma is an irregular brown hyperpigmentation mostly observed in the middle face. Although genetic predisposition, ultraviolet radiation and female sex hormones have been reported as the main causes, inflammatory processes were also considered to play a role in melasma. It has been determined that blood groups play a role in many genetic and inflammatory diseases. Since the genes that encode blood types were associated with inflammation, blood type could play a role in the etiology of melasma, an inflammatory and genetically inherited disease. The present study aimed to investigate the correlation between melasma and ABO/Rh blood types, which has never been investigated before. Material and Methods: The study was conducted 100 patients with melasma and 1000 healthy controls. The patient and healthy control blood types and Rh factor data were collected from the hospital automation system retrospectively. Results: Female gender ratio was significantly higher in the patient group compared to the control group (p<0.05). The mean patient age was significantly higher when compared to the controls (p<0.05). The analysis of the ABO blood type distribution revealed that the AB-type incidence was significantly higher in melasma patients, while the B-type incidence was higher in the control group (χ2:4.512; p<0.05). There was no significant difference between the A and 0 blood types in the patient and control groups. Rh positivity was significantly higher in the patient group (p<0.05). Conclusion: Since this is the first ABO blood type study conducted on melasma patients, multicenter studies with large samples are needed to clarify our findings.

Keywords:

ABO blood types, melasma hyperpigmentation.,

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