Kubilay İŞSEVER, Ali MUHTAROĞLU, Furkan Ali UYGUR, Muhammet Burak KAMBUROGLU

Assessing the Correlation between Helicobacter Pylori Infection and Increased Incidence of Colorectal Cancer, Gastric Atrophy, and Intestinal Metaplasia

Aim: Our retrospective study was designed to explore the potential link between Helicobacter pylori (H. pylori) infection and the occurrence of colorectal cancer (CRC), gastric atrophy, and intestinal metaplasia. Material and Methods: We assembled two groups of 150 patients each, categorized based on their endoscopic biopsy results for H. pylori - one group testing positive (study group), the other negative (control group). All subjects underwent upper and lower gastrointestinal endoscopies, and we assessed their endoscopic gastric biopsy results as well as any indications of colorectal malignancies. Results: Our investigation established a noteworthy association between the presence of H. pylori infection and the incidences of CRC, gastric atrophy, and intestinal metaplasia (p<0.05). Our data suggests that individuals testing positive for H. pylori faced a 64% greater likelihood of developing CRC compared to those who tested negative. Among patients diagnosed with gastric atrophy, a remarkable 73.9% tested positive for H. pylori. Similarly, 78.9% of patients with intestinal metaplasia were also H. pylori positive. Conclusion: Our results underscore a meaningful correlation between H. pylori infection and a heightened incidence of CRC, gastric atrophy, and intestinal metaplasia. Further, prospective studies will be instrumental in deciphering the underlying causative mechanisms and assessing the feasibility of H. pylori eradication as a preventive measure against these conditions.

Keywords:

Helicobacter pylori colorectal cancer, gastric atrophy, intestinal metaplasia, endoscopic biopsy,

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