Alper KÖKER, Meral TORUN BAYRAM, Alper SOYLU, Derya ÖZMEN, Salih KAVUKÇU, Mehmet Atilla TÜRKMEN

Clinical Features of Cases Followed with Idiopathic Hypercalciuria in Childhood, Long-term Follow-up Results and Retrospective Evaluation of Complications

Objective: The objective of this study is to assess clinical, laboratory and imaging findings, treatment styles and long-term outcomes of paediatric patients followed with idiopathic hypercalciuria (IH).Materials and Methods: We retrospectively evaluated and reviewed the files of patients aged between 3 months and 18 years with respect to age at the time of diagnosis, gender, admission complaints, follow-up period, laboratory and imaging findings (routine urinary analysis, blood and urinary biochemistry, parathormone, vitamin D level, urinary system ultrasonography and bone mineral density), onset and follow-up anthropometric data and complications.Results: The average ages of male and female patients (total: 52) diagnosed with IH were 30 and 22 years, respectively. The follow-up periods of male and female patients were 44.5±40.8 and 22.5±3.2 (6-96) months. The most frequent admission complaints were abdominal pain and underlying urinary tract infection (UTI) and history of haematuria. The average calcium level at the time of admission was 6.56±2.65 mg/kg/day, and the average calcium/creatinine level was 0.85±0.68 mg/mg. Kidney stones were determined in 41 (79%) patients. In total, 21 (40%) patients had UTI. During follow-up, UTI developed in 6 (11.5%) of them. Following medical treatment and/or nutrition recommendations, there was a reduction in the frequency of UTI rate, haematuria and enuresis (10/11 vs 6/25, p=0.030; 8/8 vs 3/33, p=0.001; and vs 1/46, p

Çocukluk Çağında İdiyopatik Hiperkalsiüri ile İzlenen Olguların Klinik Özellikleri, Uzun Dönem Takip Sonuçları ve Komplikasyonların Retrospektif İncelenmesi

Amaç: Bu çalışmada idiyopatik hiperkalsiüri (İH) tanısı ile izlenen çocuk hastaların klinik, laboratuvar, görüntüleme bulgularının, tedavi şekillerinin ve uzun süreli sonuçlarının değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: İH’li 3 ay-18 yaş arasındaki hastaların dosyaları retrospektif olarak; tanı anındaki yaş, cinsiyet, başvuru şikayeti, izlem süresi, laboratuvar ve görüntüleme bulguları (rutin idrar analizi, kan ve idrar biyokimyası, paratiroid hormon, D vitamini düzeyi, üriner sistem ultrasonografisi ve kemik mineral yoğunluğu), başlangıç ve izlemdeki antropometrik veriler ve komplikasyonlar açısından değerlendirildi. Bulgular: İH tanısı alan 52 hastanın (Erkek/Kadın: 30/22) ortalama tanı yaşı ve izlem süresi 44,5±40,8 ve 22,5±3,2 (6-96) ay idi. En sık başvuru yakınmaları sırası ile karın ağrısı, geçirilmiş idrar yolu enfeksiyonu (İYE) ve hematüri öyküsü idi. Başvuru sırasındaki ortalama idrar kalsiyum düzeyi 6,56±2,65 mg/kg/gün ve kalsiyum/kreatinin oranı da 0,85±0,68 mg/mg idi. Hastalardan 41 (%79) tanesinde tanı sırasında böbrek taşı saptandı. Hastaların 21'inde (%40) İYE geçirme öyküsü olup 6’sında (%11,5) izlem sırasında İYE gelişmişti. Medikal tedavi ve/veya beslenme önerileri sonrası hastalarda İYE sıklığı, hematüri ve enürezis sıklıklarında azalma vardı (sırasıyla 10/11 vs 6/25, p=0,030; 8/8 vs 3/33, p=0,001, 3/2 vs 1/46, p

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