Berceste GÜLER, Kevser ONBAŞI, Ezgi DOĞAN

Agresif Periodontitis Hastalarında Enflamasyon Şiddeti ile Monosit-yüksek Yoğunluklu Lipoprotein Oranı Arasındaki İlişki: Retrospektif Analiz

Amaç: Hiperlipidemi, kardiyovasküler hastalıklar için bilinen bir risk faktörüdür.Kardiyovasküler hastalıklar gibi sistemik durumlar ile periodontal hastalıklararasında ortak bir biyolojik mekanizma olduğu gösterilmiştir. Bu çalışmanın amacı,kan lipid profili ile agresif periodontitis (AgP) şiddeti arasındaki ilişkiyi incelemektir.Gereç ve Yöntemler: AgP tanısı almış toplam 32 sistemik sağlıklı hasta (24 kadın ve 8 erkek; ortalama yaş: 34,78±6,42) çalışmaya dahiledildi. Hastalar lokalize (LAgP) ve generalize agresif periodontitis (GAgP) olarak iki gruba ayrıldı. Hastalardan alınan kan örneklerindemonosit sayıları, yüksek yoğunluklu lipoprotein seviyesi (HDL) sayımı ve monosit/HDL oranları (MHR) kaydedildi. Ortalama plakindeksi, sondlamada kanama, periodontal cep derinliği ve klinik ataşman seviyesi tedavi öncesinde kaydedildi. Monosit ile HDLoranları arasındaki ilişki ile gruplar arasındaki klinik bağlanma düzeyi arasındaki ilişki Spearman korelasyonuyla analiz edildi. Bulgular: On altı GAgP ve 16 LagP hastası çalışmaya dahil edilmiştir. LAgP ve GAgP grupları için ortalama MHR değeri sırasıyla9,87±2,85 ve 13,43±4,64 olarak bulunmuştur ve gruplar arasında istatistiksel olarak anlamlı bir fark bulunmuştur (p

The Relationship Between MonocyteCount to High-density LipoproteinRatio and Severity of Inflammation inAggressive Periodontitis:A Retrospective Analysis

Objective: Hyperlipidemia is a known cardiovascular disease risk factor. A common biological mechanism between systemic diseases, such as cardiovascular diseases, and periodontal diseases has been suggested. This study aimed to examine the association between blood lipid profile and the severity of aggressive periodontitis (AgP).Materials and Methods: A total of 32 systemically healthy patients with AgP (24 females and 8 males; mean age 34.78±6.42 years) were consecutively selected. The patients were divided into 2 groups as localised AgP (LAgP) and generalised AgP (GAgP). Monocyte counts, high-density level (HDL) count and monocyte/HDL ratios (MHR) were recorded from the patients’ blood samples. Mean Plaque index, bleeding on probing, periodontal pocket depth and clinical attachment level were recorded before treatment. The relationship between monocyte to HDL ratios and clinical attachment level between the groups were analysed by Spearman correlation. Results: Sixteen GAgP and 16 LagP patients were included in the study. The mean MHR values for the LAgP and GAgP groups were 9.87±2.85 and 13.43±4.64, respectively; there was a statistically significant difference between the groups (p

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