The effect of long-term tamoxifen usage on the lower part of female genital tract in breast cancer survivors: A review

Sentetik anti-östrojenik bir ilaç olan Tamoksifen (TAM) meme kanseri tedavisinde yaygın olarak kullanılmaktadır. Uzun süreli TAM kullanımı parsiyel agonistik etkisine bağlı olarak pre-malign ve malign uterin korpus lezyonları ve fonksiyonel ovaryen kistlere yol açabilir. Bununla birlikte, meme kanseri öyküsü olan hastalarda TAM kullanımı ile aşağı kadın genital sistemi lezyonları, örneğin servikal polip ve servikal intra-epitelyal neoplazi (CIN), arasındaki ilişki hakkında literatürde çok az veri vardır. Mevcut ‘review’ bu konu hakkında güncel bir derleme sunmaktadır.

Meme kanserinde uzun süreli tamoksifen kullanımının kadın aşağı genital traktus üzerine etkisi

Tamoxifen (TAM), an anti-estrogenic synthetic drug, is widely used in the treatment of breast cancer. Due to its partial agonistic effect, long-term TAM usage may give rise to both pre-malignant and malignant uterine corpus lesions and functioning ovarian cysts. However, there are little data in the literature on the association between TAM usage and female lower genital tract lesions, such as cervical polyp and intraepithelial neoplasia (CIN), in breast cancer survivors. The present ‘review’ provides a current update on this topic.

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