Nafiye URGANCI, Fügen ÇULLU, Gülşen ÖZBAY, Bayram KIRAN, Güngör TÜMAY, Tülay ERKAN, Tufan KUTLU

Endothelin-1 levels in childhood liver disease

Objective: An in-patient with portal hypertension PH was used in a trial conducted to determine the levels of vasoconstrictors endothelin-1 (ET-1), Atrial natriuretic peptid (ANP), Angiotensin-ll, aidosterone and vasopressin, and to-investigate the correlation between ET-1 and the other hormones. Methods: The trial included 40 patients with chronic active hepatitis B (CAH-B) ( n=10), cirrhosis with portal hypertension (PH ) (n=14), cirrhosis (n=6) and extrahepatic PH (n=10). The patients were followed up for one year in the pédiatrie clinic of the Cerrahpaşa School of Medicine in Istanbul, Turkey. Nineteen of them were female and 21 of them were male, with a mean age ± Standard deviation (sd) SD of 10.2 ± 6.2 years. The control group included 10 healthy children, all of whom were male with a mean age of 9.2 ± 6 years. Plasma ET-1, ANP, Angiotensin-ll, aidosterone and vasopressin levels were measured by radioimmunoassay (RIA) method in Istanbul University, Medical School, Experimental Research Institute (DETAM), Results : Plasma ET-1 levels in chronic liver patients were higher than in the healthy control group according to One Way Analysis of Variance (ANOVA) (p=0.0001). In chronic liver disease patients, there was a positive correlation between ET-1 and aidosterone, ANP and ADH respectively r=0.45 (p=0.003), r=0.37 (p=0.003), r=0.40 (p=0.0001). In the same group, there was No correlation between ET-1 and angiotensin-ll (r=0.22, p=0.07). Conclusion: In conclusion, we found that ET-1 levels were higher in group I and IV than in the control group. Plasma ET-1 levels increase in patients diagnosed as having chronic liver disease with an undefined mechanism. This could be explained by either an increase in production or decrease in metabolic clearances or probably by both of these mechanisms.

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