Brucellosis is endemic in certain parts of the world. Musculoskeletal involvement is the most common complication of brucellosis. The spine and intervertebral discs are most frequently affected. In this case, we report the MRI findings of a brucellar spondylodiscitis located at L5-S1 level and overview of applications of MRI in brucella spondylodiscitis and its differential diagnosis.