Bir Yıl Sonunda Şehirde Yaşayan Türk Kadınındaki Human Papilloma Virus Persistans ve Klereansı
Amaç: Marmara Üniversitesi Hastanesi kadın hastalıkları polikliniğinde human papilloma virüs (HPV) pozitif saptanan kadınlarda değişik HPV genotiplerinin persistansını değerlendirmek.Hastalar ve Yöntem: İlk prevalans çalışmasında HPV DNA testi pozitif saptanan 79 kadından 40'ı bir yıl sonra tekrar değerlendirildi. HPV tipleri polymerase chain reaction (PCR) ve mikroarray hibridizasyon teknikleri ile tanımlandı.Bulgular: İlk değerlendirmenin bir yıl sonrasında kadınların %52,5'nin HPV enfeksiyonunun ortadan kalktığı; %35 ‘inin yeni bir HPV enfeksiyonu edindiği saptandı. 40 kadının %17,5'inde HPV DNA persistansı saptandı. Dokuz kadın aynı filogenetik ağaçtan HPV genotipi edinmişti. Yüksek riskli (YR) HPV tipi enfeksiyonun %43,33'ü ve düşük riskli (DR) HPV tipi enfeksiyonun %80'i ortadan kalkmıştı.Sonuç: Yüksek riskli HPV tipleri saptanan kadınlarda persistans oranı artmıştı. Çok sayıda ve karışık tipte HPV enfeksiyonları HPV genotipinin persistansında önemli etkiye sahiptir. (Marmara Üniversitesi Tıp Fakültesi Dergisi 2012;25:10-5)
Anahtar Kelimeler:
Servikal sitoloji, HPV genotipi, HPV persistansı, HPV kliransı
The Persistence and Clearance Rate of Human Papilloma Virus Genotypes in Urban Turkish Women after One Year
Objective: To evaluate the persistence of the different human papillomavirus(HPV) genotypes in women detected positive for HPV at Marmara UniversityHospital gynecologic outpatient clinics.Patients and Methods: Forty out of 79 women who had been testedpositive for HPV DNA in our initial prevalance study were re-assessed afterone year. HPV types were identified by polymerase chain reaction (PCR)and hybridization using a microarray.Results: One year after the initial assessment, 52.5% of the women had theirinitial HPV infection resolved and 35% of the women had acquired anotherHPV infection. The HPV DNA persistence was detected in 17.5% of the40 women. Nine women had acquisition of HPV genotype by the samephylogenetic clade. 43.33% of high risk (HR) HPV type and 80% of the lowrisk (LR) HPV type infection had resolved.Conclusions: The persistence rate was increased in women with HR HPVtypes. Multiple and mixed HPV infections have an important impact on thepersistence of HPV genotype. (Marmara Medical Journal 2012;25:10-5)Key Words: Cervical cytology, HPV genotype, HPV persistence, HPV clearance
Keywords:
Cervical cytology, HPV genotype, HPV persistence, HPV clearance,
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- ISSN: 1019-1941
- Yayın Aralığı: Yılda 3 Sayı
- Başlangıç: 1988
- Yayıncı: Marmara Üniversitesi
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