Hand-Schuller-Christian disease is a chronic disseminated form of Hystiocytosis-X in which there is minimal or moderate visceral involvement in addition to bone lesions. The manifestations of the disease usually begin at two or three years of age. The commonest site of origin is the intraosseous reticulum and its derivatives. In this paper a case of Hand- Schuller-Christian disease and its clinical and radiological findings have been presented.