Introduction: Fibrosis caused by chronic inflammation in the gallbladder increases the risk of biliary tract injury. Our aim was to investigate a possible correlation between pre-operative routine examinations and the degree of chronic inflammation. Materials and Methods: Samples from 74 patients with chronic cholecystitis (CC) were reevaluated to de- termine the degree of chronic inflammation. The relationship of gallbladder wall thickness and gallbladder stone size in pre-operative abdominal ultrasonography (USG), pre-operative laboratory values, and endo- scopic retrograde cholangiopancreatography (ERCP) history with the degree of histopathological chronic inflammation in the gallbladder wall was evaluated. In addition, adhesion of the surrounding tissues to the gallbladder, operation time, hospitalization period, biliary tract injury, and post-operative complications were examined in the context of degree of chronic inflammation. Results: Grade I CC was detected in 53 (69.8%) and Grade II in 21 (27.6%) patients. While the gallbladder wall was thick (>3 mm) on pre-operative USG in 7 (33.3%) patients with Grade II CC, it was normal in all patients with Grade I (p<0.001). A history of pre-operative ERCP was found in 2 (3.8%) patients in Grade I CC and in 7 (33.7%) patients in Grade II (p=0.002). In univariate and multivariate analysis, gallbladder wall thickness and history of ERCP were found to be significant in predicting the degree of chronic inflammation [(p<0.001 and p=0.002), (p=0.003 and p=0.014), respectively]. In multivariate analysis, an increase in AST value of 1 U/L increases the probability of CC grade II by 1.1 times compared to CC grade I (p=0.019). Conclusion: Increased gallbladder wall thickness, history of ERCP, and elevated AST value in CC increase the possibility of a high degree of chronic inflammation (fibrosis rate) ">
[PDF] Can the degree of fibrosis in the gallbladder wall be predicted by pre-operative routine examinations in chronic cholecystitis? A retrospective analysis | [PDF] Can the degree of fibrosis in the gallbladder wall be predicted by pre-operative routine examinations in chronic cholecystitis? A retrospective analysis
Introduction: Fibrosis caused by chronic inflammation in the gallbladder increases the risk of biliary tract injury. Our aim was to investigate a possible correlation between pre-operative routine examinations and the degree of chronic inflammation. Materials and Methods: Samples from 74 patients with chronic cholecystitis (CC) were reevaluated to de- termine the degree of chronic inflammation. The relationship of gallbladder wall thickness and gallbladder stone size in pre-operative abdominal ultrasonography (USG), pre-operative laboratory values, and endo- scopic retrograde cholangiopancreatography (ERCP) history with the degree of histopathological chronic inflammation in the gallbladder wall was evaluated. In addition, adhesion of the surrounding tissues to the gallbladder, operation time, hospitalization period, biliary tract injury, and post-operative complications were examined in the context of degree of chronic inflammation. Results: Grade I CC was detected in 53 (69.8%) and Grade II in 21 (27.6%) patients. While the gallbladder wall was thick (>3 mm) on pre-operative USG in 7 (33.3%) patients with Grade II CC, it was normal in all patients with Grade I (p<0.001). A history of pre-operative ERCP was found in 2 (3.8%) patients in Grade I CC and in 7 (33.7%) patients in Grade II (p=0.002). In univariate and multivariate analysis, gallbladder wall thickness and history of ERCP were found to be significant in predicting the degree of chronic inflammation [(p<0.001 and p=0.002), (p=0.003 and p=0.014), respectively]. In multivariate analysis, an increase in AST value of 1 U/L increases the probability of CC grade II by 1.1 times compared to CC grade I (p=0.019). Conclusion: Increased gallbladder wall thickness, history of ERCP, and elevated AST value in CC increase the possibility of a high degree of chronic inflammation (fibrosis rate) ">
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