Mahmoud ABUDAYYAK, Şeyda KANBOLAT, Şeyma BATUR, Reyyan Seda ERGENE, REZZAN ALİYAZICIOĞLU

The Biological Activity; Cytotoxicity and Antioxidant Activity of Jurinea brevicaulis

Jurinea brevicaulis is a perennial herbaceous plant belonging to theAsteraceae family. J. brevicaulis is an endemic genus and growsErzincan and Gümüşhane provinces in Turkey. Jurinea species areknown to have anticancer, antibacterial, antifungal and antioxidanteffects. In this article, it is aimed to evaluate the antioxidant capacityand cytotoxic effects of J. brevicaulis. Results indicate that, TPCvalues were between 41.7 - 537.5 GAE µg g-1, FRAP values werebetween 109.52 - 1076.2 µM Trolox equivalent g-1, CUPRAC valueswere between 231.4 - 3083.3 µM Trolox equivalent g-1, IC50 values inDPPH determination were between 0.0102 - 3.4174 mg mL-1. Theextracts caused cell death in a concentration-dependent manner in,IC50 values were calculated to be between 3.67-10.2 µg mL-1. Inconclusion, the cytotoxic effects in cancerous cells and the highantioxidant capacity indicates that J. brevicaulis could be animportant herb in developing new drugs.

Jurinea brevicaulis'in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi

Jurinea brevicaulis, Asteraceae familyasına ait çok yıllık otsu bir bitkidir. J. brevicaulis endemik bir cinstir ve Türkiye'de Erzincan ve Gümüşhane illerinde yetişir. Jurinea türleri antikanser, antibakteriyel, antifungal, antioksidan etkiler gösterdiği bilinmektedir. Bu makalede, J. brevicaulis’in antioksidan kapasitesini ve sitotoksik etkilerini değerlendirmek amaçlanmıştır. Sonuçlar, TPC değerlerinin 41.7- 537.5 GAE ug g-1 arasında, FRAP değerlerinin 109.52- 1076.2 uM Troloks eşdeğeri g-1, CUPRAC değerlerinin 231.4- 3083.3 uM Trolox eşdeğer g-1, DPPH tayininde IC50 değerleri 0.0102- 3.4174 mg mL-1 arasında olduğunu göstermektedir. Ekstreler, konsantrasyona bağlı bir biçimde hücre ölümüne neden olmuştur, IC50 değerleri 3.67-10.2 ug mL-1 arasında hesaplanmıştır. Sonuç olarak, kanser hücrelerdeki sitotoksik etkiler ve yüksek antioksidan kapasite, J. brevicaulis'in yeni ilaçların geliştirilmesinde önemli bir bitki olabileceğini göstermektedir.

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