Selinay Başak ERDEMLİ KÖSE, Fatma ŞAHİNDOKUYUCU KOCASARI, Zeki EROL, Simge GARLI

Ratlarda Toluenle İndüklenen Oksidatif Hasara Karşı p-Kumarik Asitin Antioksidan Etkisi

Bu araştırmada, fenolik asidin bir türevi olan p-CA'nın toluen kaynaklı oksidatif hasara karşı koruyucu etkisinin araştırılması amaçlanmıştır. Çalışmada, her grupta 8 olmak üzere toplam 32 Sprague-Dawley erkek sıçan kullanıldı. Kontrol, toluen, p-CA ve toluen+p-CA olarak toplam 4 grup oluşturuldu. Kontrol grubu, toluen grubu ve p-CA grubundaki hayvanlara 21 gün boyunca sırasıyla %0.9 NaCl, 0.9 mg kg-1 c.a toluen ve 100 mg kg-1 c.a p-CA verildi. Toluen+pCA grubundaki hayvanlara 3 gün boyunca p-CA verildi ve 4. günden itibaren toluen ve p-CA 25 güne kadar günlük olarak birlikte uygulandı. 25. günde çalışma sonlandırıldı ve kan örnekleri alındı. Eritrositlerde katalaz (CAT) ve glutatyon peroksidaz (GSH-Px) aktiviteleri ile malondialdehit (MDA) ve glutatyon (GSH) seviyeleri; plazma örneklerinde süperoksit dismutaz (SOD) aktivitesi belirlendi. Bu çalışmada, toluen grubunun kan örneklerinde CAT ve SOD aktiviteleri ve MDA düzeyi anlamlı (p

The Antioxidant Effect of p-Coumaric Acid Against Toluene-Induced Oxidative Stress in Rats

This research aimed to investigate the protective effect of p-CA, aderivative of phenolic acid, against toluene-induced oxidative damage.A total of 32 Sprague-Dawley male rats, 8 in each group, were used. Atotal of 4 groups were formed as control, toluene, p-CA and toluene+pCA. Animals in the control group, toluene group and p-CA group weregiven 0.9 % NaCl, 0.9 mg kg-1 b.w toluene and 100 mg kg-1 b.w p-CAorally for 21 days, respectively. The animals in toluene+p-CA groupwere received p-CA for 3 days and from day 4, toluene and p-CA wereapplied together daily until day 25. On the 25th day, the study wasterminated, and blood samples were collected. Catalase (CAT) andglutathione peroxidase (GSH-Px) activities and malondialdehyde(MDA) and glutathione (GSH) levels in the erythrocytes andsuperoxide dismutase (SOD) activity in plasma samples weredetermined. In this study, CAT and SOD activities and MDA levelsignificantly (p

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