Mustafa YILDIZ, Ahmet Çağrı AYKAN, Banu ŞAHİN YILDIZ, Gönenç KOCABAY

Yoğun Bakım Hastasında Hepatit C Virüsünün Peg-İnterferon ve Ribavirin ile Tedavisi Atriyoventriküler Nodal Reenteran Taşikardiye Neden Olabilir

Hepatit C virüsü (HCV) tedavisinde peginterferon (Peg-IFN)2b ve ribavirin tedavisi konvansiyonel interferon ve ribavirin tedavisinden daha etkilidir. Peg-IFN ve ribavirin tedavisinin önemli etkilerinin yanında ateş, halsizlik, heyecan, huzursuzluk, nötropeni ve trombositopeni gibi bir çok yan etki görülebilir. Ayrıca kardiyak aritmiler ve senkop gibi nadir olaylar da Peg-IFN tedavisine bağlı gelişebilir. Bizler bu çalışmada Peg-IFN ve ribavirin tedavisi sırasında presenkop atağı ve reenteran taşikardilerin en sık formu olan atriyoventriküler nodal reenteran taşikardi gelişen bir yoğun bakım hastasını sunuyoruz.

Anahtar Kelimeler:

Hepatit C virüsü, Peg-interferon, ribavirin, atriyoventriküler nodal reenteran taşikardi

Treatment of Hepatitis C Virus with Peginterferon and Ribavirin May Trigger Atrioventricular Nodal Reentrant Tachycardia in An Intensive Care Unit Patient

The treatment of hepatitis C virus (HCV) with peginterferon (Peg-IFN) α2b and ribavirin is more effective than with conventional interferon and ribavirin. Despite the important effects of Peg-IFN and ribavirin therapy, many side effects, such as fever, fatigue, anxiety, irritability, neutropenia and thrombocytopenia, may be observed. In addition, cardiac arrhythmias and syncope are rare consequences of Peg-IFN therapy. In this study, we report an intensive care unit patient who developed atrioventricular nodal reentrant tachycardia (AVNRT), which is the most common type of reentrant supraventricular tachycardia, and presyncopal attack during Peg-IFN and ribavirin therapy.

Keywords:

Hepatitis C virus, peginterferon, ribavirin, atrioventricular nodal reentrant tachycardia,

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1. Wilkins T, Malcolm JK, Raina D, Schade RR. Hepatitis C: diagnosis and treatment. Am Fam Physician 2010;81:1351-7.
2. Okanoue T, Sakamoto S, Itoh Y, Minami M, Yasui K, Sakamoto M, et al. Side effects of high-dose interferon therapy for chronic hepatitis C. J Hepatol 1996;25:283-91.
3. El-Atrebi K, El-Bassyouni HT. Management of rare side effects of peginterferon and ribavirin therapy during hepatitis C treatment: a case report. Cases J 2009;2:7429.
4. Katritsis DG, Camm AJ. Atrioventricular nodal reentrant tachycardia. Circulation 2010;122:831-40.
5. Yildiz M, Aykan AC, Kahveci G, Demir S, Ozkan M. Transvenous radiofrequency ablation theraphy as an effective and safe method for the treatment of the slow pathway of atrioventricular nodal re-entrant tachycardia. Koşuyolu Heart J 2011;14:51-5.