Ömer Gedikli, Sinan Şahin, Caner KARAHAN, Merih Kutlu

Stabil Koroner Arter Hastalarında “Arterial Stiffness” ile Asetilsalisilik Asidin Etkinliği Arasında Bir İlişki Var mıdır?

Giriş: Bu çalışmada stabil koroner arter hastalarında "arterial stiffness (AS)" ile asetilsalisilik asidin etkinliği arasında ilişki olup olmadığı araştırılmıştır. Hastalar ve Yöntem: Çalışmaya stabil koroner arter hastalığı olan (anjiyografi k olarak dokümante edilmiş) ve en az bir hafta boyunca 100 mg asetilsalisilik asit kullanan 82 ardışık hasta alındı. AS'ın değerlendirilmesinde aortik nabız dalga hızı (NDH) ve augmentasyon indeksi (AIx) kullanıldı. Bu parametreler SphygmoCor cihazı ile ölçüldü. Asetilsalisilik asidin etkinliği serum tromboksan (Tx) B2 düzeyleriyle değerlendirildi. Bulgular: Çalışma grubunun yaş ortalaması 63 ± 9 yıl idi. Çalışma grubunda aortik NDH 11.7 ± 2.8 (m/sn) ve AIx 28 ± 9 (%) olarak bulundu. Hastaların serum TxB2 düzeyleri 428 ± 1312 (mg/ dL) idi. Serum TxB2 ile AS parametreleri olan aortik NDH (r= 0.01, p= 0.8) ve AIx (r= 0.1, p= 0.4) arasında anlamlı ilişki saptanmadı. Ancak total kolesterol (r= 0.21, p= 0.05) ve LDL kolesterol (r= 0.25, p= 0.02) düzeyleri ile serum TxB2 düzeyleri arasında anlamlı korelasyon saptandı. Sonuç: Bu çalışmanın bulguları stabil koroner arter hastalarında AS ile asetilsalisilik asidin etkinliği arasında ilişki olmadığını düşündürmektedir.

Anahtar Kelimeler:

Arterial stiffness, asetilsalisilik asit, tromboksan B2.

Is There a Relationship Between the Arterial Stiffness and Effectiveness of Acetylsalicylic Acid in Patients with Stable Coronary Artery Disease?

Introduction: We aimed to investigate whether arterial stiffness (AS) is associated with effectiveness of acetylsalicylic acid in patients with stable coronary artery disease. Patients and Methods: We enrolled 82 consecutive stable coronary artery disease patients taking at least one week acetylsalicylic acid. AS was evaluated by aortic pulse wave velocity (PWV) and augmentation index (AIx). These parameters were measured with Sphygmo- Cor device. Acetylsalicylic acid effi cacy was evaluated by serum thromboxane B2 (TxB2) level. Results: The mean age was 63 ± 9 years. Aortic PWV was 11.7 ± 2.8 (m/sec) and AIx was 28 ± 9 years (%), in the study group. Serum TxB2 level was 428 ± 1312 (mg/dL). There was no signifi cant correlation between serum TxB2 level and AS parameters. However, total cholesterol (r= 0.21, p= 0.05) and LDL cholesterol (r= 0.25, p= 0.02) levels were signifi cantly correlated with the serum levels of TxB2. Conclusion: The fi ndings of this study suggest that there is no relationship between AS and effi cacy of acetylsalicylic acid in patients with stable coronary artery disease.

Keywords:

Arterial stiffness, acetylsalicylic acid, tromboxane B2.,

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ISSN: 2149-2972
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 1990
Yayıncı: Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Yüksek İhtisas Eğitim ve Araştırma Hastanesi