Gebelikte Speckle Tracking Ekokardiyografisi ile Değerlendirilen Anne Kalbinin Mekanik Fonksiyonlarının Değişimi
Giriş: Bu çalışmanın amacı sağlıklı gebelerde, gebelik süresince ve sonrasında sol
ventrikül fonksiyonlarındaki değişimi “iki boyutlu speckle tracking
ekokardiyografi (STE)” yöntemi ile araştırmaktır.
Hastalar ve
Yöntem: Çalışmaya 86 sağlıklı gebe dahil edilmiş ve gebeliğin
birinci trimester 8-12 hafta, ikinci trimester 20-24 hafta, üçüncü trimester
32-36 hafta ve postpartum 10-14. haftada 2 boyutlu ekokardiyografi ile
kayıtları alınmıştır. Sol ventrikül global longitüdinal strain (SV-GLS), sol
ventrikül global radiyal strain (SV-GRS), sol ventrikül global sirkumferansiyel
strain (SV-GCS) değerleri not edilmiştir.
Bulgular: SV-GLS birinci trimester için -%21.0 ± 2.1; ikinci. trimester için -%19.9 ±
1.8; üçüncü trimester için -%18.2 ± 2.1; postpartum -%19.1 ± 1.4, p< 0.001).
SV-GCS gebelik boyunca anlamlı olarak azalırken (p= 0.033), post partum dönemde
1.ci trimesterde bulunan değerlerine yükseldi. SV-GRS değerlerinde gebelik
boyunca değişiklikler istatistiksel olarak anlamlı bulunmadı (p= 0.103).
Sonuç: Bu çalışmada STE ile
değerlendirilen, SV-GLS ve SV-GCS ile mekanik fonksiyonlarının anlamlı bir
şekilde değiştiğini ve SV-GRS’de bir değişim olmadığını saptadık.
Alteration of Pregnant Women Heart Mechanics Assessed by Speckle Tracking Echocardiography During Pregnancy
Introduction:
The
purpose of this study was to evaluate left ventricular myocardial mechanics
using 2-dimensional speckle tracking echocardiography (2D-STE) during normal,
uncomplicated pregancy and postpartum term.
Patients
and Methods: In this prospective, longitudinal study, 86 healthy
pregnant women who underwent serial 2 dimensional echocardiographic evaluation
during each trimester (trimester one 8-12 weeks; trimester two 20-24 weeks,
trimester three 32-36 weeks, and postpartum 10-14 weeks). Two-dimensional STE
was performed to measure global left ventricular longitudinal, circumferential,
and radial strain (GLS, GCS, and GRS, respectively).
Results: GLS showed
a decrease during pregnancy (for first trimester 21.0 ± 2.1%; for second
trimester 19.9 ± 1.8%; for third trimester 18.2 ± 2.1; for postpartum 19.1 ±
1.4, p< 0.001). GCS was significantly reduced during pregnancy (p= 0.033)
and peaked as the same value in the first trimester. GRS remained unchanged
throughout the pregnancy and labor (p= 0.033).
Conclusion: This study gives normal
ranges of 2D indices in pregnancy. 2D STE demonstrated that LV longitudinal and
circumferantial strain are significantly reduced, whereas radial strain
remained unchanged.
___
- 1. Siu SC, Sermer M, Colman JM, Alvarez AN, Mercier LA, Morton BC, et al. Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation 2001;104:515-21.
- 2. Mabie WC, DiSessa TG, Crocker LG, Sibai BM, Arheart KL. A longitudinal study of cardiac output in normal human pregnancy. Am J Obstet Gynecol 1994;170:849-56.
- 3. Cong J, Fan T, Yang X, Squires JW, Cheng G, Zhang L, et al. Cardiovasc Ultrasound 2015;13:6.
- 4. Robson SC, Hunter S, Boys RJ, Dunlop W. Serial study of factors influencing changes in cardiac output during human pregnancy. Am J Physiol 1989;256:H1060-5.
- 5. Gilson GJ, Samaan S, Crawford MH, Qualls CR, Curet LB. Changes in hemodynamics, ventricular remodeling, and ventricular contractility during normal pregnancy: a longitudinal study. Obstet Gynecol 1997;89:957-62.
- 6. Gilson GJ, Mosher MD, Conrad KP. Systemic hemodynamics and oxygen transport during pregnancy in chronically instrumented, conscious rats. Am J Physiol 1992;263:H1911-8.
- 7. Valensise H, Novelli GP, Vasapollo B, Borzi M, Arduini D, Galante A, et al. Maternal cardiac systolic and diastolic function: relationship with uteroplacental resistances. A Doppler and echocardiographic longitudinal study. Ultrasound Obstet Gynecol 2000;15:487-97.
- 8. Geyer H, Caracciolo G, Abe H, Wilansky S, Carerj S, Gentile F, et al. Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications. J Am Soc Echocardiogr 2010;23:351-69.
- 9. Gottdiener JS, Bednarz J, Devereux R, Gardin J, Klein A, Manning WJ, et al. American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr 2004;17:1086-119.
- 10. Quinones MA, Otto CM, Stoddard M, Waggoner A, Zoghbi WA; Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr 2002;15:167-84.
- 11. Savu O, Jurcut R, Giusca S, van Mieghem T, Gussi I, Popescu BA, et al. Morphological and functional adaptation of the maternal heart during pregnancy. Circ Cardiovasc Imaging 2012;5:289-97.
- 12. Ando T, Kaur R, Holmes AA, Brusati A, Fujikura K, Taub CC. Physiological adaptation of the left ventricle during the second and third trimesters of a healthy pregnancy: a speckle tracking echocardiography study. Am J Cardiovasc Dis 2015;5:119-26.
- 13. Sengupta SP, Bansal M, Hofstra L, Sengupta PP, Narula J. Gestational changes in left ventricular myocardial contractile function: new insights from two-dimensional speckle tracking echocardiography. Int J Cardiovasc Imaging 2017;33:69-82.
- 14. Sengupta PP, Narula J. Reclassifying heart failure: predominantly subendocardial, subepicardial, and transmural. Heart Fail Clinyöhkujj 2008;4:379-82.