Meme kanserli hastalarda serum Seladin-1/DHCR24 düzeyinin araştırılması

Amaç: Meme kanseri kadınlarda önemli bir morbidite ve mortalite nedenidir. Desmosterolden kolesterol oluşum reaksiyonunu katalizleyen enzim olan Seladin-1 daha önce çeşitli tümör türlerinde farklı düzeylerde exprese edildiği gözlenmiştir. Çalışmamızda; serum seladin-1 düzeyleri ile metastatik olmayan meme kanseri hastalarının klinik özellikleri arasındaki ilişkiyi ve seladin-1'in meme kanserinde prognostik değerini araştırmayı amaçladık.Yöntem: Tıbbi onkoloji kliniğimizde, 18 yaş üstü, histopatolojik olarak meme kanseri tanısı almış, cerrahi olarak tümör dokusu çıkarılmış, herhangi bir onkolojik tedavi henüz almamış, uzak organ metastazı ve ek malignitesi olmayan hastalar ile kontrol grubu olarak sağlıklı kadın gönüller çalışmaya dahil edildi. Demografik veriler ve laboratuvar verileri kaydedildi. Serum seladin-1 düzeyleri hasta ve kontrol grupları arasında karşılaştırıldı. Bulgular: 46 hasta ve 27 kontrol grubu olmak üzere toplam 73 kadın hasta çalışmaya dahil edildi. Hasta grubunun yaş ortalaması 56±12 yıl, kontrol grubunun 62±12 yıldı (p=0.055) Seladin-1 düzeyleri gruplar arasında karşılaştırıldığında; hasta grubunda kontrol grubuna göre daha düşük seviyede saptandı (p=0.038). Tümör boyutları ile Seladin-1 düzeyi arasında istatistiksel bir ilişki yoktu. (p=0.138). Bunun yanında, hastaların stage ve gradelerine göre seladin-1 düzeyi karşılaştırıldığında istatistiksel fark olmadığı görüldü (p=0,720; p=0,092, sırasıyla). Sonuç: Çalışmamızda meme kanseri hastalarının serumlarında seladin-1 düzeyi kontrol grubuna göre daha düşük saptandı. Ne var ki, meme kanserinin prognostik faktörleri ile seladin-1 düzeylerinin ilişkili olmadığı görülmüştür. Seladin-1’in meme kanserli hastalarında düşük olmasının altında yatan mekanizmaların aydınlatılabilmesi için daha ileri araştırmalar gerekmektedir.

Anahtar Kelimeler:

Meme kanseri, Seladin-1, DHCR24, Prognostik değer

Investigation of serum Seladin-1 / DHCR24 levels in breast cancer patients

Objective: Seladin-1, an enzyme that catalyzes the cholesterol formation reaction from desmosterol, has been shown to be expressed at different levels in various types of tumor. The purpose of this study was to investigate the relationship between serum seladin-1 levels and clinical characteristics of patients with non-metastatic breast cancer, and to examine the prognostic value of seladin-1 in breast cancer. Method: Patients aged 18 and over diagnosed with breast cancer using histopathological methods at our medical oncology clinic, whose tumor tissue had been surgically removed and who had not yet received any oncological treatment, and with no distant organ metastasis or additional malignancy, and healthy women volunteers as a control group were included in the study. Demographic and laboratory data were recorded. Serum seladin-1 levels were compared between the patient and control groups. Results: Seventy-three women, 46 patients and 27 controls, were enrolled. Mean ages were 56±12 years in the patient group and 62±12 in the control group (p=0.055) Seladin-1 levels were lower in the patient group than in the control group (p=0.038). No statistically significant relationship was observed between tumor size and seladin-1 levels (p=0.138). No relationship was also determined between patient grades and stages and seladin-1 (p=0.720; p=0.092, respectively). Conclusion: Seladin-1 levels were lower in the serum of breast cancer patients than in the control group. However, no statistically significant relationship was found between breast cancer prognostic factors and seladin-1 levels. Further research is needed to clarify the mechanisms underlying the low seladin-1 levels in breast cancer patients.

Keywords:

Breast cancer, , seladin-1 , DHCR24, , prognostic value,

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ISSN: 1309-3878
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2009
Yayıncı: Düzce Üniversitesi Tıp Fakültesi Aile Hekimliği AD adına Yrd.Doç.Dr.Cemil Işık Sönmez