PROSTAT SPESİFİK ANTİJEN VE BÖBREK FONKSİYON TESTLERİ ARASINDAKİ İLİŞKİNİN NEDENİ: YAŞ

AMAÇ: İleri yaş erkeklerde sık görülmekte olan prostat ve böbrek hastalıklarının tarama, tanı ve tedavi takiplerinde kullanılmakta olan prostat spesifik antijen (PSA) ve kreatinin, tahmini glomerüler filtrasyon hızı (eGFR), üre ürik asit düzeyleri arasındaki ilişkilerin araştırılması amaçlandı. GEREÇ VE YÖNTEM: Eylül 2017 – Mart 2020 tarihleri arasında 40 yaş ve üzerindeki 7203 erişkin erkek hastaya ait eş zamanlı olarak istenmiş olan serum PSA, kreatinin, üre ve ürik asit sonuçları retrospektif olarak incelendi. Parametreler arasındaki korelasyonlar yaşın etkisi ile birlikte değerlendirildi. Ek olarak PSA yüksekliği ile eGFR azalışı arasındaki çift yönlü ilişki de incelendi. BULGULAR: Yaş değişkeni kontrol edildiğinde; PSA düzeyleri üzerine kreatinin, üre ve ürik asit düzeylerinin bir etkisi olmadığı (sırasıyla; p=0,63, p=0,28 ve p=0,39), benzer şekilde PSA düzeylerinin de kreatinin, üre ve ürik asit düzeyleri üzerine bir etkisi olmadığı gözlendi (sırasıyla; p=0,22, p=0,25 ve p=0,92). Yaş değişkeni ile birlikte yapılan regresyon analizlerinde; yaş arttıkça PSA yüksekliği görülme riski 1.09 kat artmakta iken kreatinin arttıkça ise riskin anlamlı bir değişim göstermediği tespit edildi (sırasıyla; p<0,001 ve p=0,99). Benzer şekilde yaş arttıkça orta ve ileri derecede eGFR azalış riski 1.11 kat artmakta iken PSA arttıkça ise riskin anlamlı bir değişim göstermediği tespit edildi (sırasıyla; p<0,001 ve p=0,31). SONUÇ: Çalışmanın bulguları ışığında; yaş arttıkça PSA ve kreatinin düzeylerinin yükselme riski artarken, yaş değişkeni kontrol edildiğinde PSA ve kreatinin düzeyleri arasındaki ilişkinin ortadan kalktığı ve yüksekliklerinin birbirleri üzerine etkisinin olmadığı sonucuna ulaşıldı.

Anahtar Kelimeler:

Prostat spesifik antijen, Prostat, Kreatinin, Üre, Böbrek hastalığı

THE CAUSE OF THE RELATIONSHIP BETWEEN PROSTATE SPECIFIC ANTIGEN AND RENAL FUNCTION ASSOCIATED PARAMETERS: AGE

OBJECTIVE: It was aimed to investigate the relationships between creatinine, estimated glomerular filtration rate (eGFR), urea, uric acid and prostate specific antigen (PSA) levels, that are used in screening, diagnosis and follow-up of prostate and kidney diseases that are common in older man. MATERIAL AND METHODS: Simultaneously requested serum PSA, creatinine, urea and uric acid results of 7203 males above 40 years old between September 2017 and March 2020 were retrospectively analyzed. The correlations between parameters were evaluated with the effect of age. In addition, the bidirectional relationship between PSA elevation and eGFR decrease was also examined. RESULTS: There were no effect of creatinine, urea and uric acid levels on PSA levels (p=0.63, p=0.28 and p=0.39, respectively) and similarly, there were no effect of PSA levels on creatinine, urea and uric acid levels (p=0.22, p=0.25 and p=0.92, respectively) when adjusted for age. In the regression analysis with age; while the risk of PSA elevation increased 1.09 times as age increased, it was found that the risk did not show a significant change as creatinine increased (p<0.001 and p=0.99, respectively). Similarly, while the risk of moderate/severe eGFR decrease increased 1.11 times as age increased, it was found that the risk did not show a significant change as PSA increased (p<0.001 and p=0.31, respectively). CONCLUSIONS: In the light of the findings of the study, it is concluded that the risk of increased PSA and creatinine levels increases with advancing age. The relationship between PSA and creatinine levels disappears and they do not effect each other when age variable is taken into account.

Keywords:

Prostate specific antigen, Prostate, Creatinine, Urea, Kidney disease,

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