TİROİD OFTALMOPATİ HASTALARINDA IN VIVO KONFOKAL MİKROSKOPİ KULLANILARAK LANGERHANS HÜCRELERİNİN DEĞERLENDİRİLMESİ: RETROSPEKTİF BİR ÇALIŞMA
Amaç: Tiroid orbitopati (TAO) hastalarında görülen oküler yüzey hastalığında inflamasyonun rolünün in vivo konfokal mikroskopi (IVKM) ile korneal Langerhans hücre (LH) yoğunluğu araştırılarak değerlendirilmesi. Yöntem: Otuz üç inaktif hasta [(Klinik Aktivite Skoru (KAS)
EVALUATION OF CORNEAL LANGERHANS CELLS IN PATIENTS WITH THYROID OPHTHALMOPATHY BY USING AN IN VIVO CONFOCAL MICROSCOPY: A RETROSPECTIVE STUDY
Objective: To assess corneal Langerhans cell (LC) density in thyroid-associated ophthalmopathy (TAO) patients to evaluate the role ofinflammation in ocular surface disease related to TAO by using in vivo confocal microscopy (IVCM).Methods: Thirty-three patients who had inactive disease [(Clinical Activity Score (CAS)
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- 1. Kishazi E, Dor M, Eperon S, Oberic A, Hamedani M, Turck N. Thyroid-associated orbitopathy and tears: A proteomics study. J Proteomics. 2018;170:110-116. doi:10.1016/j.jprot.2017.09.001
- 2. Ismailova DS, Fedorov AA, Grusha YO. Ocular surface changes in thyroid eye disease. Orbit. 2013;32(2):87-90. doi:10.3109/01676830.2013.764440
- 3. Selter JH, Gire AI, Sikder S. The relationship between Graves' ophthalmopathy and dry eye syndrome. Clin Ophthalmol. 2014;9:57-62. doi:10.2147/OPTH.S76583
- 4. Iskeleli G, Karakoc Y, Abdula A. Tear film osmolarity in patients with thyroid ophthalmopathy. Jpn J Ophthalmol. 2008;52(4):323-326. doi:10.1007/s10384-008-0545-7
- 5. Ujhelyi B, Gogolak P, Erdei A, Nagy V, Balazs E, Rajnavolgyi E et al. Graves' orbitopathy results in profound changes in tear composition: a study of plasminogen activator inhibitor-1 and seven cytokines. Thyroid. 2012;22(4):407-414. doi:10.1089/thy.2011.0248
- 6. Gürdal C, Saraç O, Genç I, Kırımlıoğlu H, Takmaz T, Can I. Ocular surface and dry eye in Graves' disease. Curr Eye Res. 2011;36(1):8-13. doi:10.3109/02713683.2010.526285
- 7. Rocha EM, Mantelli F, Nominato LF, Bonini S. Hormones and dry eye syndrome: an update on what we do and don't know. Curr Opin Ophthalmol. 2013;24(4):348-355. doi:10.1097/ICU.0b013e32836227bf
- 8. Abusharaha A, Alturki AA, Alanazi SA, Fagehi R, Al-Johani N, El-Hiti GA, Masmali AM. Assessment of tear-evaporation rate in thyroid-gland patients. Clin Ophthalmol. 2019;13:131- 135. doi:10.2147/OPTH.S188614
- 9. Choi EY, Kang HG, Lee CH, Yeo A, Noh HM, Gu N et al. Langerhans cells prevent subbasal nerve damage and upregulate neurotrophic factors in dry eye disease. PLoS One. 2017;12(4):e0176153. doi:10.1371/journal.pone.0176153
- 10. Hamrah P, Huq SO, Liu Y, Zhang Q, Dana MR. Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. J Leukoc Biol. 2003;74(2):172-178. doi:10.1189/jlb.1102544
- 11. Lin H, Li W, Dong N, Chen W, Liu J, Chen L et al. Changes in corneal epithelial layer inflammatory cells in aqueous teardeficient dry eye. Invest Ophthalmol Vis Sci. 2010;51(1):122- 128. doi:10.1167/iovs.09-3629
- 12. Fiore T, Torroni G, Iaccheri B, Cerquaglia A, Lupidi M, Giansanti F et al. Confocal scanning laser microscopy in patients with postoperative endophthalmitis. Int Ophthalmol. 2019;39(5):1071-1079. doi:10.1007/s10792-018-0916-0
- 13. Mandathara PS, Stapleton FJ, Kokkinakis J, Willcox MDP. A pilot study on corneal Langerhans cells in keratoconus. Cont Lens Anterior Eye. 2018;41(2):219-223. doi:10.1016/j.clae.2017.10.005
- 14. Resch MD, Imre L, Tapaszto B, Nemeth J. Confocal microscopic evidence of increased Langerhans cell activity after corneal metal foreign body removal. Eur J Ophthalmol. 2008;18(5):703-707. doi:10.1177/112067210801800507
- 15. Bartalena L, Baldeschi L, Dickinson A, Eckstein A, KendallTaylor P, Marcocci C et al. Consensus statement of the European Group on Graves' orbitopathy (EUGOGO) on management of GO. Eur J Endocrinol. 2008;158(3):273-285. doi:10.1530/EJE-07-0666
- 16. Marsovszky L, Resch MD, Németh J, Toldi G, Medgyesi E, Kovács L et al. In vivo confocal microscopic evaluation of corneal Langerhans cell density, and distribution and evaluation of dry eye in rheumatoid arthritis. Innate Immun. 2013;19(4):348-354. doi:10.1177/1753425912461677
- 17. Villani E, Viola F, Sala R, Salvi M, Mapelli C, Currò N et al. Corneal involvement in Graves' orbitopathy: an in vivo confocal study. Invest Ophthalmol Vis Sci. 2010;51(9):4574- 4578. doi:10.1167/iovs.10-5380
- 18. Wei YH, Chen WL, Hu FR, Liao SL. In vivo confocal microscopy of bulbar conjunctiva in patients with Graves' ophthalmopathy. J Formos Med Assoc. 2015;114(10):965- 972. doi:10.1016/j.jfma.2013.10.003
- 19. Wu LQ, Cheng JW, Cai JP, Le QH, Ma XY, Gao LD et al. Observation of Corneal Langerhans Cells by In Vivo Confocal Microscopy in Thyroid-Associated Ophthalmopathy. Curr Eye Res. 2016;41(7):927-932. doi:10.3109/02713683.2015.1133833
- 20. Lin H, Li W, Dong N, Chen W, Liu J, Chen L et al. Changes in corneal epithelial layer inflammatory cells in aqueous teardeficient dry eye. Invest Ophthalmol Vis Sci. 2010;51(1):122- 128. doi:10.1167/iovs.09-3629
- 21. Marsovszky L, Németh J, Resch MD, Toldi G, Legány N, Kovács L et al. Corneal Langerhans cell and dry eye examinations in ankylosing spondylitis. Innate Immun. 2014;20(5):471-477. doi:10.1177/1753425913498912