Effect of Vitamin D Level on Post-Thyroidectomy Hypocalcemia

INTRODUCTION: In this study, the effect of preoperative vitamin D levels on postoperative hypocalcemia was investigated. METHODS: We retrospectively investigated 106 patients who were operated for benign – malign thyroid nodules or thyrotoxicosis and whose preoperative vitamin D levels were measured in the General Surgery Clinic of Sakarya University Education and Reserch Hospital between January 2015 and March 2016. RESULTS: The average age of the patients is 50,6 (min: 19, max: 82). There were 94 female and 12 male patients. When the vitamin D levels of the patients undergoing thyroidectomy were evoluated, it was found that 59,8% (n: 63) deficient, 20,8% (n: 22) insufficient (30 ng/dl). Transient hypocalcemia symptoms developed in 18,9% of the postoperative patients and the patients had received calcium (Ca) therapy. When factors affecting the occurence of hypocalcemia symptoms were examined, it was seen that age, hyperthyroidism, thyroiditis, parathyroid gland removal and operation type did not affect the postoperative hypocalcemia symptom status; however, patients with vitamin D below 30 ng/dl had more hypocalcemia 23,3% & 0%)(p: 0,017). DISCUSSION and CONCLUSION: As suggested by our study and other studies, preoperative vitamin D levels should be assested in every patient who will undergo thyroidectomy and vitamin D replacement should be performed in every patient who has insufficiency..

Vitamin D Düzeylerinin Tiroidektomi Sonrası Gelişen Hipokalsemi Üzerine Etkisi

GİRİŞ ve AMAÇ: Bu çalışmada preoperatif olarak ölçülen D vitamini düzeylerinin postoperatif olarak gelişen hipokalsemiler üzerine etkisi araştırılmıştır YÖNTEM ve GEREÇLER: Araştırmamıza 2015 yılı ocak ayı ile 2016 yılı Mart ayı arasında Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi Genel Cerrahi Kliniğinde benign, malign ya da tirotoksikoz nedeni ile opere edilen ve preoperatif olarak D vitamini düzeyi bakılmış 106 hasta retrospektif olarak dahil edilmiştir. BULGULAR: Hastaların yaş ortalaması 50,6dır (min: 19 max: 82). Hastaların 94’ü kadın 12’si ise erkektir. Tiroidektomi yapılan hastaların preoperatif vitamin D düzeyleri değerlendirildiğinde %81,1’inde (n: 86) yetmezlik (30 ng/dl) olduğu görülmüştür. Postoperatif hastaların %18,9’unda geçici hipokalsemi semptomları gelişmiş olup, hastalar kalsiyum (Ca) tedavisi almıştır. Hipokalsemi semptomlarının oluşmasına etki eden faktörler incelendiğinde; yaş, hipertiroidi, tiroidit, paratiroid bezinin çıkartılması ve operasyon tipinin postoperatif hipokalsemi semptom varlığını etkilemez iken,

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E. Yetkin. Tiroid Hastalıkları ve cerrahisi, ‘Tiroidektomi komplikasyonları’. Ed: A. İşgör. Avrupa Tıp Kitapçılık Baskı 1, 2000; 10:583-95.

Demirer S. Tiroidektomi Komplikasyonları. Türkiye Klinikleri J Surg Med Sci 2005;1:71-6.

Bergamaschi R, Becouarn G, Ronceray J, et al. Morbidity of thyroid surgery. Am J surg1998; 176:71-5.

Lambordi CP, Raffaelli M, Princi P, et al. Early prediction of postthyroidectomy hypocalcemia by one single İPTH measurement. Surgery . 2004; 136 (6): 1236-41.

Quiros RM, Pesce CE, Wilhelm SM, Djuricin G, Prinz RA. İntraoperative parathyroid hormone levels in thyroid surgery are predictive of postoperative hypoparathyroidism and need for vitamin D supplementation. Am J Surg. 2005 Mar;189 (3): 306-9.

Uruno T, Miyauchi A, Shimizu K, et al. A prophylactic infusion of calcium solution reduces the risk of symptomatic hypocalcemia in patients after total thyroidectomy. World J Surg. 2006;30 (3):304- 8.

Lindblom P, Westerdahl J, Bergenfelz A. Low parathyroid hormone levels after thyroid surgery: a feasible predictor of hypocalcemia. Surgery. 2002; 131 (5): 515-20.

Lin Y, Ross H, Raeburn C, et al. Vitamin D deficiency does not increase the rate of postoperative hypocalcemia after thyrkoidectomy. Am J Surg. 2012; 204:888-94.

Griffin TP, Murphy MS, Sheahan P. Vitamin D and risk of postoperative hypocalcemia after total thyroidectomy. JAMA Otolaryngol Head Neck Surg. 2014; 140: 346-351.

Lang BH, Wong KP, Cheung CY, Foung YK, Chan DK, Hung GK. Does preoperative 25- hydroxyvitamin D status significantly affect the calcium kinetics after total thyroidectomy? World J Surg. 2013; 37: 1592-8.

Salinger EM, Moore JT. Perioperative indicators of hypocalcemia in total thyroidectomy: the role of vitamin D and parathyroid hormone. Am J Surg. 2013;206: 876-81.

Nhan C, Dolev Y, Mijovic T, et al. Vitamin D deficiency and the risk of hypocalcemia following total thyroidectomy. J Otolaryngol Head Neck Surg. 2012; 41:401-6.

Erbil Y, Ozbey NC, Sari S, et al. Determinants of postoperative hypocalcemia in vitamin D deficient Graves patients after total thyroidectomy. Am J Surg. 2011; 201: 685- 91.

Erbil Y, Barbaros U, Temel B, et al. The impact of age, vitamin D level and incidental parathyroidectomy on postoperative hypocalcemia after total or near total thyroidectomy. Am J Surg. 2009; 197:439-46.

Kirkby-Bott J, Markogiannakis H, Skandarajah A, Cowan M, Fleming B, Palazzo F. Preoperative vitamin D deficiency predicts postoperative hypocalcemia after total thyroidectomy. World J Surg. 2011; 35:324-30.

Yamashita H, Murakami T, Noguchi S, et al. Postoperative tetany in Graves disease: important role of vitamin D metabolites. Ann Surg. 1999; 229:237-45.

Chia SH, Weisman RA, Tieu D, Kelly C, Dilimann WH, Orloff LA. Prospective study of perioperative factors predicting hypocalcemia after thyroid and parathyroid surgery. Arch Otolaryngol Head Neck Surg. 2006; 132:41-5.

Bozec A, Dassonville O, Chamorey E, et al. Clinical impact of cervical lymph node involvement and central neck dissection in patients with papillary thyroid carcinoma : a retrospective analysis of 368 cases. Eur Arch Otorhinolaryngol. 2011; 268:1205- 12.

Genser L, Tresallet C, Godiris-Petit G, et al. Randomized controlled trial of alfacalcidol suplementation fort he reduction of hypocalcemia after total thyroidectomy. Am J Surg. 2014;207:39- 45.

Asari R, Passler C, Kaczirek K, Scheuba C, Niederle B. Hypoparathyroidism after total thyroidectomy: a prospective study. Arch Surg. 2008;143:132-7.
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  • ISSN: 2147-0758
  • Başlangıç: 2012
  • Yayıncı: -
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