Asymmetric tremor due to possible valproic acid-aripiprazole interaction in a child with severe intellectual disability

ntellectual disability is a common neurodevelopmental disorder. Antipsychotic drugs, mood stabilizers drugs are often used in this group for behavioral problems. Tremor as a symptom can develop due to the use of both valproic acid and aripiprazole which is usually manifested as symmetrical.When valproate and ari-piprazole are administered together, there may be some change in plasma concentrations of aripiprazole and its metabolite but this change is thought to be related to the displacement in plasma proteins thus effect of both drugs on changes to steady state levels is very small and not clinically significant We report the case of a 15-year-old girl is that asymmetric tremor, which occurs after valproic acid is added to treatment while using aripiprazole, and the disappearance of asymmetric tremor after reducing the dose of aripiprazole.

Şiddetli entellektüel yetiyitimi olan bir çocukta olası valproik asit-aripiprazol etkileşimi ile ilişkili asimetrik tremor

Entellektüel yetiyitimi yaygın görülen bir nörogelişimsel bozukluktur. bu grupta çocuklar meydana gelen davranış problemlerinin tedavisinde antipsikotik ilaçlar, duygu durum dengeleyiciler sıklıkla kullanılmaktadır. Tremor, hem valproik asit hem de aripiprazol kullanımı nedeniyle gelişebilir ve genelikle simetrik olması beklenmektedir. Valproat ve aripiprazol birlikte uygulandığında, aripiprazol ve metabolitinin plazma konsantrasyonlarında bazı değişiklikler olabilir, ancak bu değişikliğin plazma proteinlerindeki yer değiştirmeyle ilişkili olduğu düşünülmektedir, bu nedenle her iki ilacın kararlı durum seviyelerindeki değişiklikler üzerindeki etkisi çok küçüktür ve klinik olarak önemsiz kabul edilmektedir. bu vaka sunumunda aripiprazol kullanırken tedaviye valproik asit eklenmesi sonrası asitmetrik tremor gelişen sonrasında aripiprazolun dozu azaltığında asitmetrik tremoru kesilen 15 yaşındaki kız olgu sunulmuştur.

Kaynakça

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Kaynak Göster

Klinik Psikiyatri Dergisi
  • ISSN: 1302-0099
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1998

9b5.7b

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