Mehmet ALKANAT, Hafize ÖZDEMİR, Şükrücan BAYTAN

SIÇANLARDA SİMVASTATİN UYGULAMASI İLE OLUŞAN ANKSİYOJENİK-BENZERİ DAVRANIŞTA NİTRİK OKSİTİN ETKİSİ

Amaç: 3-hidroksi-3-metil-glutaril-koenzim A redüktaz enzimini inhibe ederek kolesterol sentezini engelleyen statinler tüm dünyada hiperlipidemilerin tedavisinde yaygın olarak kullanılmaktadır. Statin ailesinin önemli bir üyesi olan simvastatinin, çeşitli çalışmalarda nitrik oksit miktarını arttırdığı gösterilmiştir. Bu çalışmada, simvastatin kullanımına bağlı olarak değişen anksiyete seviyesine, nitrik oksit düzeyinin etki edip etmediği araştırıldı.

Anahtar Kelimeler:

Statinler, Simvastatin, anksiyete, Nitrik oksit, yükseltilmiş artı labirent, açık alan

Effect of Nitric Oxide on Anxiogenic-like Behavior Induced by Simvastatin Administration in Rats

Objective: Statins which inhibit cholesterol synthesis by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase enzymes are used widely for treatment of hyperlipidemia. In this study, altered anxiety levels by simvastatin use have been investigated to assess whether these effects are caused by changed nitric oxide levels.

Keywords:

statins, simvastatin, anxiety, nitric oxide, elevated plus maze, open field,

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