Aydın KANT, Şenol ÇOMOĞLU, Sinan ÖZTÜRK, Ercan AYDIN, Gürdal YILMAZ

KRONİK OBSTRÜKTİF AKCİĞER HASTALIĞI COVID-19 ENFEKSİYONUNUN ŞİDDETİNİ ETKİLİYOR MU?

Amaç: Kronik obstrüktif akciğer hastalığı (KOAH) olan hastalar koronavirüs hastalığı-2019 (COVID-19) mortalitesi açısından yüksek riske sahiptir. Bu risk, eşlik eden diğer hastalıkların varlığı ile daha da artmaktadır. Çalışmamızda KOAH’lı hastalarda COVID-19’un şiddetinin belirlenmesi amaçlanmıştır.

Anahtar Kelimeler:

COVID-19, KOAH, Hastalık şiddeti

Does Chronic Obstructive Pulmonary Disease Affect the Severity of COVID-19 Infection?

Objective: Coronavirus disease-2019 (COVID-19) has a high risk of mortality in patients with chronic obstructive pulmonary disease (COPD). This risk increases with the presence of other comorbid diseases. In our study, it was aimed to determine the severity of COVID-19 in patients with COPD.

Keywords:

COVID-19, COPD, disease severity,

PDF

___

1. Zhang L, Liu Y. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol. 2020;92(5):479-90. Doi:10.1002/jmv.25707.
2. World Health Organization (WHO). Q&A on smoking and COVID‐19. Accessed date: 30 June 2020:www.who.int/publications/i/item/WHO-2019-nCoV-Sci_Brief-Smoking-2020.2.
3. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475-81.
4. Lange P, Celli B, Agustí A, Boje Jensen G, Divo M, Faner R et al. Lung-function trajectories leading to chronic obstructive pulmonary disease. N Engl J Med. 2015;373(2):111-22.
5. Global Strategy for Prevention, Diagnosis and Management of COPD Accessed date: 03 December 2020: https://goldcopd.org/wp‐content/uploads/2019/12/GOLD‐2020‐FINAL‐ver1.2
6. Wedzicha JA. Role of viruses in exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2004;1(2):115‐20.
7. Frickmann H, Jungblut S, Hirche TO, Gross U, Kuhns M, Zautner AE. The influence of virus infections on the course of COPD. Eur J Microbiol Immunol (Bp). 2012;2(3):176‐85.
8. Kefala AM, Fortescue R, Alimani GS, Kanavidis P, McDonnell MJ, Magiorkinis E et al. Prevalence and clinical implications of respiratory viruses in stable chronic obstructive pulmonary disease (COPD) and exacerbations: a systematic review and meta‐analysis protocol. BMJ Open. 2020;10(4):e035640. Doi:10.1136/bmjopen-2019-035640.
9. Lippi G, Henry BM. Chronic obstructive pulmonary disease is associated with severe coronavirus disease 2019 (COVID‐19). Respir Med. 2020;167:105941.
10. Leung JM, Yang CX, Tam A, Shaipanich T, Hackett TL, Singhera GK et al. ACE‐2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID‐19. Eur Respir J. 2020;55(5):2000688.
11. Wilkinson TM, Hurst JR, Perera WR, Wilks M, Donaldson GC, Wedzicha JA. Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD. Chest. 2006;129(2):317‐24. Doi:10.1378/chest.129.2.317.