Diyabet ve Sistemik Enflamasyon Parametrelerinin Bell Palsisinin Prognozuna Etkisi

Amaç: Bell palsili hastalarda, diyabetin prognostik önemini, nötrofil-lenfosit oranı, trombosit-lenfosit oranı, sistemik inflamasyon yanıt indeksi dahil hematolojik ve biyokimyasal test bulgularını değerlendirmek, ayrıca Bell palsili hastalarda trigliserid-glikoz indeksini değerlendirmek ve bu sonuçları sağlıklı deneklerle karşılaştırmaktır.

EFFECT OF DIABETES AND SYSTEMIC INFLAMMATION PARAMETERS ON THE PROGNOSIS OF BELL’S PALSY

Objective: This study aimed to evaluate the prognostic importance of diabetes mellitus, hematologic and biochemical test findings including neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic inflammation response index and triglyceride-glucose index in patients with Bell’s palsy and to compare these results with healthy subjects.

___

  • 1. Baugh RF, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R et al. Clinical practice guideline: Bell's palsy. Otolaryngol Head Neck Surg. 2013;149(3 Suppl):S1-27.
  • 2. Peitersen E. Bell's palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol Suppl. 2002;(549):4-30.
  • 3. Eviston TJ, Croxson GR, Kennedy PG, Hadlock T, Krishnan AV. Bell's palsy: aetiology, clinical features and multidisciplinary care. J Neurol Neurosurg Psychiatry. 2015;86(12):1356-61.
  • 4. Greco A, Gallo A, Fusconi M, Marinelli C, Macri GF, de Vincentiis M. Bell's palsy and autoimmunity. Autoimmun Rev. 2012;12(2):323-8.
  • 5. Riga M, Kefalidis G, Danielides V. The role of diabetes mellitus in the clinical presentation and prognosis of Bell palsy. J Am Board Fam Med. 2012;25(6):819-26.
  • 6. Liou LS, Chang CY, Chen HJ, Tseng CH, Chen CY, Sung FC. Increased risk of peripheral arterial occlusive disease in patients with Bell's palsy using population data. PLoS One. 2017;12(12):e0188982.
  • 7. Zhang W, Xu L, Luo T, Wu F, Zhao B, Li X. The etiology of Bell's palsy: a review. J Neurol. 2020;267(7):1896-905.
  • 8. Chweya CM, Anzalone CL, Driscoll CLW, Lane JI, Carlson ML. For whom the Bell's toll: Recurrent facial nerve paralysis, a retrospective study and systematic review of the literature. Otol Neurotol. 2019;40(4):517-28.
  • 9. Pitsavos C, Tampourlou M, Panagiotakos DB, et al. Association between low-grade systemic inflammation and type 2 diabetes mellitus among men and women from the ATTICA Study. Rev Diabet Stud. 2007;4(2):98-104.
  • 10. Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis GA, Vogiatzi G, Papaioannou S et al. The Role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol. 2019;14(1):50-59.
  • 11. Schmidt MI, Duncan BB, Sharrett AR, Lindberg G, Savage PJ, Offenbacher S et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet. 1999;353(9165):1649-52.
  • 12. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006;116(7):1793-801.
  • 13. Şevik ES, Erdem D. Does type 2 diabetes mellitus affect the healing of bell's palsy in adults? Can J Diabetes. 2018;42(4):433-6.
  • 14. Cai Z, Li H, Wang X, Niu X, Ni P, Zhang W et al. Prognostic factors of Bell's palsy and Ramsay Hunt syndrome. Medicine (Baltimore). 2017;96(2):e5898.
  • 15. Lee HY, Byun JY, Park MS, Yeo SG. Effect of aging on the prognosis of Bell's palsy. Otol Neurotol. 2013;34(4):766-70.
  • 16. Fujiwara T, Hato N, Gyo K, Yanagihara N. Prognostic factors of Bell's palsy: prospective patient collected observational study. Eur Arch Otorhinolaryngol. 2014;271(7):1891-5.
  • 17. Kanazawa A, Haginomori S, Takamaki A, Nonaka R, Araki M, Takenaka H. Prognosis for Bell's palsy: a comparison of diabetic and nondiabetic patients. Acta Otolaryngol. 2007;127(8):888-91.
  • 18. Guerrero-Romero F, Simental-Mendía LE, González-Ortiz M, Martínez-Abundis E, Ramos-Zavala MG, Hernández-González SO et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab. 2010;95(7):3347-51.
  • 19. Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008;6(4):299-304.
  • 20. Simental-Mendía LE, Hernández-Ronquillo G, Gómez-Díaz R, Rodríguez-Morán M, Guerrero-Romero F. The triglycerides and glucose index is associated with cardiovascular risk factors in normal-weight children and adolescents. Pediatr Res. 2017;82(6):920-5.
  • 21. Unger G, Benozzi SF, Perruzza F, Pennacchiotti GL. Triglycerides and glucose index: a useful indicator of insulin resistance. Endocrinol Nutr. 2014;61(10):533-40.
  • 22. Horibe Y, Tanigawa T, Shibata R, Nonoyama H, Kano F, Yamaguchi S et al. Efficacy of the red blood cell distribution width for predicting the prognosis of Bell palsy: a pilot study. Eur Arch Otorhinolaryngol. 2017;274(5):2303-6.
  • 23. Kim HS, Jung J, Dong SH, Kim SH, Jung SY, Yeo SG. Association between high neutrophil to lymphocyte ratio and delayed recovery from Bell's Palsy. Clin Exp Otorhinolaryngol. 2019;12(3):261-6.
  • 24. Oya R, Takenaka Y, Imai T, Sato T, Oshima K, Ohta Y et al. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as prognostic hematologic markers of Bell's palsy: A Meta-analysis. Otol Neurotol. 2019;40(5):681-7.
  • 25. Bucak A, Ulu S, Oruc S, Yucedag F, Tekin MS, Karakaya F et al. Neutrophil-to-lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. Laryngoscope. 2014;124(7):1678-81.
  • 26. Wasano K, Kawasaki T, Yamamoto S, Tomisato S, Shinden S, Ishikawa T et al. Pretreatment hematologic findings as novel predictive markers for facial Palsy prognosis. Otolaryngol Head Neck Surg. 2016;155(4):581-7.
  • 27. Eryilmaz A, Basal Y, Tosun A, Kurt Omurlu I, Basak S. The neutrophil to lymphocyte ratios of our pediatric patients with Bell's palsy. Int J Pediatr Otorhinolaryngol. 2015;79(12):2374-7.
  • 28. Geng Y, Zhu D, Wu C, Wu J, Wang Q, Li R et al. A novel systemic inflammation response index (SIRI) for predicting postoperative survival of patients with esophageal squamous cell carcinoma. Int Immunopharmacol. 2018;65:503-10.
  • 29. Wasano K, Ishikawa T, Kawasaki T, Yamamoto S, Tomisato S, Shinden S et al. Novel pre-therapeutic scoring system using patient and haematological data to predict facial palsy prognosis. Clin Otolaryngol. 2017;42(6):1224-8.
  • 30. Engström M, Jonsson L, Grindlund M, Stålberg E. House-Brackmann and Yanagihara grading scores in relation to electroneurographic results in the time course of Bell's palsy. Acta Otolaryngol. 1998;118(6):783-9.
  • 31. Devriese PP, Schumacher T, Scheide A, de Jongh RH, Houtkooper JM. Incidence, prognosis and recovery of Bell's palsy. A survey of about 1000 patients (1974-1983). Clin Otolaryngol Allied Sci. 1990;15(1):15-27.
  • 32. Jung SY, Jung J, Byun JY, Park MS, Kim SH, Yeo SG. The effect of metabolic syndrome on Bell's palsy recovery rate. Acta Otolaryngol. 2018;138(7):670-4.
  • 33. Liu W, Fan Z, Han Y, Xu L, Wang M, Zhang D et al. Activation of NF-κB signaling pathway in HSV-1-induced mouse facial palsy: Possible relation to therapeutic effect of glucocorticoids. Neuroscience. 2015;289:251-61.
  • 34. Qi Q, Zhuang L, Shen Y, Geng Y, Yu S, Chen H et al. A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy. Cancer. 2016;122(14):2158-67.
Kırıkkale Üniversitesi Tıp Fakültesi Dergisi-Cover
  • ISSN: 2148-9645
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1999
  • Yayıncı: KIRIKKALE ÜNİVERSİTESİ KÜTÜPHANE VE DOKÜMANTASYON BAŞKANLIĞI
Sayıdaki Diğer Makaleler

Deli Bal Zehirlenmelerinde Acil Servis Gözlemi Yeterli Midir? Vaka Sunumu

Metin OCAK OCAK, Nur YURT

YOĞUN BAKIM HASTALARINDA İNFLAMASYON BELİRTEÇLERİNİN MORTALİTE TAHMİNİNDE KULLANIMI

Meltem AKTAY, Dilek ÖZCENGİZ, Dilek DESTEGÜL, Özlem ÖZKAN KUŞCU, Ferit KUŞCU

AÇIK KALP CERRAHİSİNDE 72 SAATLİK TRİMETAZİDİN UYGULAMASININ MİYOKARD İSKEMİSİ ÜZERİNE ETKİLERİ

Hüseyin GEMALMAZ, Yıldırım GÜLTEKİN, Tuğrul KURAL

Çocuk ve Ergenlerde Dikkat Eksikliği Hiperaktivite Bozukluğu Tedavisinin İnternet Oyun Oynama Bozukluğu, Sosyal Medya Bağımlılığı ve Siber Zorbalık Üzerine Olan Etkisinin Değerlendirilmesi

Arif Hakan ÖNDER, Özge GİZLİ ÇOBAN, Aslı Sürer ADANIR, Gözde DOKUZ, Zehra Ece SOĞUCAK

PATOLOJİ SONUCU UTERİN LEİOMYOM OLARAK SONUÇLANAN OLGULARIN HEMATOLOJİK İNFLAMATUAR BELİRTEÇLER İLE RETROSPEKTİF DEĞERLENDİRİLMESİ

Demet AYDOĞAN KIRMIZI, Emre BAŞER, Taylan ONAT, Melike DEMİR ÇALTEKİN, Mustafa KARA, Ethem Serdar YALVAÇ, Ayla GENÇER

ANJİNA BÜLLOZA HEMORAJİKA: BİR OLGU SUNUMU

Gülşah ERTAŞ, Melda MISIRLIOĞLU, MEHMET ZAHİT ADIŞEN, Merve AYDOĞDU, Zahide MEŞHUR

Çocuk Hastada İnflamatuar Odontojenik Kist: Olgu Sunumu

Kamile Nur TOZAR, Merve ERKMEN ALMAZ, Hatice ÖNDER, Fethi ATIL, Emre BARIŞ

YASSI PİL YUTULMASINA BAĞLI GELİŞEN ÖZOFAGUS PERFORASYONU VE KONSERVATİF TEDAVİSİ: OLGU SUNUMU

Cem KAYA, Hayrunnisa ORAL, Kamercan CEYLAN, Ramazan KARABULUT, Ödül EĞRİTAŞ GÜRKAN, Zafer TÜRKYILMAZ, Kaan SÖNMEZ

GERİATRİK AKUT APANDİSİTLERİN TANI VE TEDAVİSİNDEKİ FARKLILIKLAR: TEK MERKEZ DENEYİMİ

Ahmet ERDOĞAN, Ahmet TÜRKAN, Uğur KILINÇ

İNSİDENTAL SAPTANAN MEZENTERİK KALSİFİYE FİBRÖZ TÜMÖR: OLGU SUNUMU

Mahi BALCI, Merve ERYOL