Burak Mustafa TAŞ, Gökçe ÖZEL, Müyesser ARAS, Rahmi KILIÇ

Bell Paralizi Tedavisinde Alfa Lipoik Asitin Etkinliğinin Değerlendirilmesi

Amaç: Bu çalışma, Bell paralizisi tedavisinde alfa-lipoik asidin etkinliğini House-Brackmann derecelendirme sistemi ve elektromyografi kullanarak değerlendirmeyi amaçlamaktadır.

Anahtar Kelimeler:

Alfa-lipoik Asit, Elektromyografi, House-Brackmann Derecelendirme Sistemi, Bell paralizi

EVALUATION OF THE EFFECTIVENESS OF ALPHA LIPOIC ACID IN THE TREATMENT OF BELL'S PALSY

Objective: This study aims to evaluate the efficacy of alpha-lipoic acid in the treatment of Bell’s palsy by using the House-Brackmann grading system and electromyography.

Keywords:

Alpha-lipoic acid, Bell’s palsy, Electromyography, House-Brackmann grading system,

PDF

___

1. Baugh RF, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R et al. Clinical practice guideline: Bell's palsy. Otolaryngol Head Neck Surg. 2013;149(3 Suppl):1-27.
2. Salinas RA, Alvarez G, Daly F, Ferreira J. Corticosteroids for Bell’s palsy (idiopathic facial paralysis). Cochrane Database Syst Rev. 2010;(3):CD001942.
3. Lockhart P, Daly F, Pitkethly M, Comerford N, Sullivan, F. Antiviral treatment for Bell’s palsy (idiopathic facial paralysis). Cochrane Database Syst Rev. 2009;(4):CD001869.
4. Gantz BJ, Rubinstein JT, Gidley P, Woodworth GG. Surgical management of Bell’s palsy. Laryngoscope. 1999;109(8):1177-88.
5. de Sousa CNS, da Silva Leite CMG, da Silva Medeiros I, Vasconcelos LC, Cabral LM, Patrocínio CFV et al. Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review. Metab Brain Dis. 2019;34(1):39-52.
6. Yang L, Wen Y, Lv G, Lin Y, Tang J, Lu J et al. α-Lipoic acid inhibits human lung cancer cell proliferation through Grb2-mediated EGFR downregulation. Biochem Biophys Res Commun. 2017;494(1-2):325-31.
7. Nagamatsu M, Nickander KK, Schmelzer JD, Raya A, Wittrock DA, Tritschler H et al. Lipoic acid improves nerve blood flow, reduces oxidative stress and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18(8):1160–7.
8. Han T, Bai J, Liu W, Hu Y. A systematic review and meta-analysis of a-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol. 2012;167(4):465–71.
9. Eviston TJ, Croxson GR, Kennedy PG, Hadlock T, Krishnan AV. Bell's palsy: aetiology, clinical features and multidisciplinary care. J Neurol Neurosurg Psychiatry. 2015;86(12):1356-61.
10. Croxson GR. The assessment of facial nerve dysfunction. J Otolaryng Soc Austral. 1990;4:252–63.
11. Bayındır T, Tan M, Selimoğlu E. Diagnosis and management of Bell palsy. KBB-Forum. 2011;10(1).
12. House JW, Brackmann DE. Facial nerve grading system. Otolaryngol Head Neck Surg. 1985;93(2):146–7.
13. Jung SY, Jung J, Byun JY, Park MS, Kim SH, Yeo SG. The effect of metabolic syndrome on Bell's palsy recovery rate. Acta Otolaryngol. 2018;138(7):670-4.
14. Madhok VB, Gagyor I, Daly F, Somasundara D, Sullivan M, Gammie F et al. Corticosteroids for Bell's palsy (idiopathic facial paralysis). Cochrane Database Syst Rev. 2016;7(7):CD001942.
15. Agathos E, Tentolouris A, Eleftheriadou I, Katsaouni P, Nemtzas I, Petrou A et al. Effect of α-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy. J Int Med Res. 2018;46(5):1779-90.
16. Papanas N, Ziegler D. Efficacy of α-lipoic acid in diabetic neuropathy. Expert OpinPharmacother. 2014;15(18):2721-31.
17. Vasconcelos GS, Ximenes NC, de Sousa CN, Oliveira Tde Q, Lima LL, de Lucena DF et al. Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms. Schizophr Res. 2015;165(2-3):163-70.
18. Ziegler D, Hanefeld M, Ruhnau KJ, Meissner HP, Lobisch M, Schütte K et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia. 1995;38(12):1425-33.
19. Ametov AS, Barinov A, Dyck PJ, Hermann R, Kozlova N, Litchy WJ et al. The sensory symptoms of diabetic polyneuropathy are improved with alphalipoic acid. The SYDNEY Trial. Diabetes Care 2003;26(3):770-6.
20. Ziegler D, Low PA, Freeman R, Tritschler H, Vinik AI. Predictors of improvement and progression of diabetic polyneuropathy following treatment with α-lipoic acid for 4 years in the NATHAN 1 trial. J Diabetes Complications. 2016;30(2):350-6.