Boyun yerleşimli hiyalin vasküler tip castleman hastalığı: İki olgu

Castleman hastalığı, nedeni kesin bilinmeyen lenfoproliferatif bir hastalıktır. En sık mediastinal lenf nodlarını tutmasına rağmen servikal bölge, retroperitoneal, aksiller ve diğer lenf nodu bölgeleri de tutulabilmektedir. Yazımızda boyunda soliter kitle ile kendini gösteren hiyalin vasküler tip Castleman Hastalığı olan iki hasta literatür eşliğinde sunuldu. Her iki olguda başka patoloji saptanmadı ve kitlelerin ince iğne aspirasyon biyopsileride benign özellikte bulundu. Malignite riski nedeniyle her iki kitle total olarak çıkarıldı, Histopatolojik incelemelerde hiyalin vasküler tip Castleman Hastalığı tanısı kondu ve iki senelik takipte nüks gözlenmedi.

Hyaline vascular type castleman's disease of the neck: Two cases

Castleman's disease is a lymphoproliferative disorder which have unknown etiology. It can involve mostly mediastinal lymph nodes however the disease can be seen in cervical, retroperitoneal, axillary and other lymph node regions. In this article two patients with hyaline vascular type Castleman's disease presenting with solitary neck mass were discussed and literatures were reviewed. There was not any other pathology and FNAB showed non malignant. Two masses were excised totally for the risk of malignancy. Histopathologic examination revealed hyalin vasculer type Castleman's disease. Two years follow up showed no recurrence.

Kaynakça

1) Castleman B, Iverson L, Menendez P. Localized mediastinal lymph-node hyperplasia resembling thymoma. Cancer 1956; 9: 822–830. [ Özet ]

2) Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 1972; 29: 670–683. [ Özet ]

3) Castleman B. Case report of the Massachusetts General Hospital. N Engl J Med 1954; 250: 26–30. [ Özet ]

4) Seco JL, Velasco F, Manuel JS, Serrano SR, Thomas L, Velasco A. Retroperitoneal Castleman's Disease. Surgery 1992; 112: 850–855. [ Özet ]

5) Gangopadhyay K, Mahasin ZZ, Kfoury H. Pathologic quiz case 2. Castleman disease (giant lymph node hyperplasia). Arch Otolaryngol Head Neck Surg 1997; 123: 1137–1139. [ Özet ]

6) Kooper DP, Tiwari RM, van der Valk P. Castleman disease as an uncommen cause of a neck mass. Eur Arch Oto-Rhino-Laryngol 1994; 251: 370–372. [ Özet ]

7) Glazer M, Rao VM, Reiter D, McCue P. Isolated Castleman disease of the neck: MR findings. AJNR Am J Neuroradiol 1995; 16: 669–671. [ Özet ]

8) Sanchez-Cuellar A, de Pedro M, Martin-Granizo R, Berguer A. Castleman disease (giant lymph node hyperplasia) in the maxillofacial region: a report of 3 cases. J Oral Maxillofac Surg 2001;59: 228–231. [ Özet ]

9) Herrada J, Cabanillas F, Rice L, Manning J, Pugh W. The clinical behavior of localized and multicentric Castleman Disease. Ann Intern Med 1998; 128: 657-663. [ Özet ]

10) Nishimoto N, Sasai M, Shima Y, Nakagawa M, Matsumoto T, Shirai T, Kishimoto T, Yoshizaki K. Improvement in Castleman's disease by huminazed anti-interleukin-6 receptor antibody therapy. Blood 2000; 95: 56–61. [ Özet ]

11) Shahidi H, Myers JL, Kvale PA. Castleman' s disease. Mayo Clin Proc 1995; 70: 969–977. [ Özet ]

12) Yoshizaki K, Matsuda T, Nishimoto N, Kuritani T, Taeho L, Aozasa K. et al. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 1989; Sep; 74(4): 1360–1367. [ Özet ]

13) Taura T, Takashima S, Shakudo M, Kaminou T, Yamada R, Isoda K. Castleman's disease of the spleen: CT, MR imaging and angiographic findings. Eur J Radiol 2000; 36: 11–15. [ Özet ]

Kaynak Göster