Bahri ÖZER, Oğuz ÇATAL, Songül PELTEK ÖZER, Mustafa SİT, Hayri ERKOL

Yaşlı Erkeklerde Malign Tiroid Hastalıklarının Genel Özellikleri

Amaç: Tiroid bezi boynun derin fasyaları arasına yerleşen önemli bir endokrin organdır. Günümüzde tiroid cerrahisi, özellikle malignite için gerçekleştirilmektedir. Tiroidektomi uygulanan yaşlı erkek hastalarda malignite oranlarını ve sonuçlarını araştırmayı amaçladık. Materyal- metot: Tiroidektomi yapılan hastaların verilerini inceledik. Kadın hastalar çalışma dışı bırakıldı. Erkek hastalar iki gruba ayrıldı; Grup 1'de 60 yaşın altında ve grup 2'de 60 yaşın üstü. Histopatolojik sonuçlara göre hastalar benign ve malign olarak sınıflandırıldı. Malign olanların tümör büyüklüğü her grupta birbiriyle karşılaştırıldı. Ayrıca malign grupta tümörün histolojik alt tipi ve çok odaklı olması kaydedilmiştir. Tüm hastaların demografik parametreleri ve patolojik bulguları kaydedildi ve SPSS yazılımı ile istatistiksel olarak analiz edildi. İstatiksel olarak p değerei <0,05 olması anlamlı kabul edildi. Bulgular: Çalışmaya dahil edilen toplam hasta 727(% 20) idi . Grup1 tüm vakaların % 82,3'ünü (n = 598), Grup 2 ise tüm vakaların% 17,7'sini (n = 129) oluşturuyordu. Malign hastaların yaş ortalaması grup 1'de 46, grup 2'de 67 idi. Histopatolojik sonuçlara göre; yaşlı erkek hastalarda malignite yüzdesi daha yüksekti. Ortalama tümör çapı grup 1'de 16.3 mm ve grup 2'de 20,3 mm idi. Multicentricitide, grup 2'nin 12 (%44,4) vakasında ve grup 1'in 26'sında (%26) mevcuttu. Sonuç: Çalışmamızda yaşlı erkek hastalarda; Tiroid kanseri insidansı, tümör boyutu ve multicentricitide olma genç hastalardan daha yüksektir

Anahtar Kelimeler:

Tiroid, , Kanser, Yaşlı erkek

General Characteristics of Benign and Malignant Thyroid Conditions in Elderly Men

Objective: The thyroid gland is an important endocrine organ which settled between the deep fascias of the neck. Nowadays thyroid surgery is performing especially for malignancy. We aimed to investigate the rates and consequences of malignancy in older male patients who underwent thyroidectomy. Material-Method: We analyzed the data of patients who underwent thyroidectomy. Female patients were excluded from the study. Male patients were divided into two groups; under the age of 60 as Group 1 and over the age of 60 as group 2. According to histopathological results, patients were classified as benign and malignant. Tumor size of malignant ones compared with each other in each group. Also in malignant group ;histological subtype of the tumor and tumor focality- multicentriticy were investigated and multicencritic ones were noted. The demographic parameters and pathological findings of all patients were recorded and statistically analyzed by SPSS software. Results: A total of 727 (%20) male patients included in the study. Group 1 was accounted for 82.3% (n=598) and group 2 was accounted for 17.7%(n=129) of all cases. The average age of malignant patients was 46 in group 1 and was 67 in group 2. According to the histopathological results; the percentage of malignancy was higher in older male patients. The average tumor diameter was 16.3 mm in group 1 and 20.3 mm in group 2. The multicenticity was present in 12 (44.4%) cases of group 2 and in 26 (26%) cases of group 1. Conclusion:In our study in elderl men patients ; thyroid cancer insidance, tumor size and multicentricity is higher than the younger patients

Keywords:

Thyroid, Cancer, Elderly men,

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1. Nguyen QT, Lee EJ, Huang MG, Park YI, Khullar A, Plodkowski RA. Diagnosis and treatment of patients with thyroid cancer. American health & drug benefits. 2015;8(1):30.
2. Hay ID, Grant CS, Taylor WF, McConahey WM. Ipsilateral lobectomy versus bilateral lobar resection in papillary thyroid carcinoma: a retrospective analysis of surgical outcome using a novel prognostic scoring system. Surgery. 1987;102(6):1088-95.
3. Cady B, Rossi R. An expanded view of risk-group definition in differentiated thyroid carcinoma. Surgery. 1988;104(6):947-53.
4. Edge SB, Byrd D, Compton C, Fritz A, Greene F, Trotti A. American Joint Committee on Cancer cancer staging manual. New York: Springer; 2010.
5. DEGROOT LJ, KAPLAN EL, MCCORMICK M, STRAUS FH. Natural history, treatment, and course of papillary thyroid carcinoma. The Journal of Clinical Endocrinology & Metabolism. 1990;71(2):414-24.
6. Haymart MR. Understanding the relationship between age and thyroid cancer. The oncologist. 2009;14(3):216-21.
7. Sosa JA, Udelsman R. Total thyroidectomy for differentiated thyroid cancer. Journal of surgical oncology. 2006;94(8):701-7.
8. Dean DS, Hay ID. Prognostic indicators in differentiated thyroid carcinoma. Cancer control. 2000;7(3):229-39.
9. Papaleontiou M, Haymart MR. Approach to and treatment of thyroid disorders in the elderly. Medical Clinics. 2012;96(2):297-310.
10. Nammas W, Mostafa M, Sabry I, Abdel-Aziz M, Kabil H. Thyroid hormone patterns in elderly patients undergoing elective coronary procedures. Eur Rev Med Pharmacol Sci. 2011;15(2):175-80.
11. Christmas C, Makary MA, Burton JR. Medical considerations in older surgical patients. Journal of the American College of Surgeons. 2006;203(5):746-51.
12. Fassnacht M, Kreissl MC, Weismann D, Allolio B. New targets and therapeutic approaches for endocrine malignancies. Pharmacology & therapeutics. 2009;123(1):117-41.
13. Benek S, Kocakuşak A, Özer B, Kızılkaya MC, Erözgen F, Çiftçi F, et al. Tamamlayıcı Tiroidektominin Son Dekadda Değişen Yapısı. 2015; 53:225-8
14. Morris LG, Sikora AG, Tosteson TD, Davies L. The increasing incidence of thyroid cancer: the influence of access to care. Thyroid. 2013;23(7):885-91.
15. Milas Z, Shin J, Milas M. New guidelines for the management of thyroid nodules and differentiated thyroid cancer. Minerva Endocrinol. 2011;36(1):53-70.