Evaluation of the Prognostic Value of Preoperative Neutrophil-tolymphocyte Ratio in Renal Cell Carcinoma

Objective: To investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in renal cell carcinoma (RCC). Materials and Methods: Preoperative NLR value in 125 patients who underwent surgical treatment for renal tumor between January 2012 and September 2017 and and received the pathological diagnosis of RCC, was evaluated. The patients were initially divided into two groups as patients with and without metastases at the time of diagnosis. Subsequently, the patients were divided into two groups according to the pathological stage. In the first group, patients with localized RCC (pT1 and pT2) were evaluated and in the other group, those with advanced RCC (pT3 and pT4) were evaluated, and then, these two groups were compared. Results: The mean NLR was higher in group with metastasis than in group without metastasis at the time of diagnosis (4.4±2.8 and 2.9±1.6, respectively; p=0.029). When a NLR of 3.1 was taken as the cut-off value; it was observed that the NRL value in 7 of 8 patients with metastasis at diagnosis was above 3.1. (p=0.002, OR=14.6). Overall survival was 59.8±2.7 months and 49±4.5 months in patients with a NLR of 3.1, respectively (p=0.045). Conclusion: We assume that preoperative NLR can be evaluated as a prognostic marker for overall survival in patients with RCC.

Renal Hücreli Kanserlerde Preoperatif Nötrofil Lenfosit Oranının Prognostik Belirteç Olarak Değerlendirilmesi

Amaç: Renal hücreli kanserlerde (RHK) prognostik belirteç olarak nötrofil lenfosit oranının (NLO) etkinliğini araştırmak. Gereç ve Yöntem: Ocak 2012 - Eylül 2017 tarihleri arasında böbrek tümörü nedeniyle cerrahi tedavi uygulanan ve RHK patolojisi olan 125 hastanın preoperatif NLO’su değerlendirildi. Hastalar ilk tanı anında metastaz olanlar ve olmayanlar olarak iki gruba ayrıldı. Ardından hastalar patolojik T evresine göre iki gruba ayrıldı. İlk grupta T1 ve T2 evreli lokalize hastalar, diğer grupta T3 ve T4 evreli invaziv hastalar değerlendirilerek veriler bu iki grup arasında karşılaştırılarak incelendi. Bulgular: NLO tanı anında metastazı olan grupta, metastazı olmayan gruba oranla daha yüksekti (sırasıyla 4,4±2,8 ve 2,9±1,6; p=0,029). NLO=3,1 değeri sınır değer olarak alındığında tanı anında metastatik olan 8 hastanın 7’sinin değeri 3,1’in üzerinde olduğu gözlendi (p=0,002, OR=14,6). NLO 3,1 olan hastalarda 49±4,5 ay olarak saptandı (p=0,045). Sonuç: Bu çalışmada preoperatif NLO, RHK hastalarında genel sağkalım açısından prognostik belirteç olarak değerlendirilebileceği gösterilmiştir.

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Kaynak Göster

  • ISSN: 2148-9580
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2014

2.5b 1.7b

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