PRIMARY SPINAL CORD GLIOBLASTOMA IN YOUNG POPULATION; REPORT OF TWO CASES

Primary spinal glioblastoma is a very rare disease of spinal cord with high morbidity and mortality. In this study, we presented two patients surgically treated for primary spinal glioblastoma. The first case was a 21-year-old male who has a lesion at T9-T10 spinal level in Magnetic resonance imaging (MRI) in which subtotal resection was performed. The second case was a 22-year-old male patient who has a lesion in the spinal canal between the level of C3 andT1 in MRI. The lesion was resected subtotally. The pathological diagnosis was reported as glioblastoma in both cases. Primary spinal glioblastoma is a very rare disease. Because of its clinically and radiologically malignant behavior of prognosis, this disease must be kept in mind in differential diagnosis of cervical-thoracal spinal cord pathologies and early diagnosis and treatment should be started as soon as possible.

Kaynakça

1. Scarrow AM, Rajedran P, Welch WC, Glioblastoma multiform of the conus medullaris. Clin Neural Neurosurg. 2000; 102:166-7.

2. Andrews AA, Enriques L, Renaudin J, Tomiyasu U. Spinal intramedullary glioblastoma with intracranial seeding. Report of a case. Arch Neurol. 1978;35:244-5.

3. Cooper PR. Outcome after operative treatment of intramedullary spinal cord tumors in adults: intermediate and long-term results in 51 patients. Neurosurgery. 1989;25:855-9.

4. Ciapetta P, Salvati M, Capoccia G, Artico M, Raco A, Fortuna A. Spinal glioblastomas: report of seven cases and review of the literature. Neurosurgery. 1991;28:302-6.

5. Caroli E, Salvati M, Ferranate L. Spinal glioblastoma with brain relapse in child: Clinical considerations. Spinal Cord. 2005;43:565-68.

6. Shen CX, Wu JF, Zhao W, Cai ZW, Cai RZ, Chen CM. Primary spinal glioblastoma multiforme, A case report and review of the literature. Medicine (Baltimore). 2017;96:e6634.

7. Takara E, Ide M, Yamamato M, Imanaga H, Jimbo M, Imai M. A case of the intracranial and spinal dissemination of primary spinal glioma. No Shinkei Geka. 1985;13:301-5.

8. Acıkgöz B, Kalaycı M, Sanser G. Intramedullary spinal cord tumors. Turkey Clinics, J Surg Med Sci. 2007;3:150-6.

9. Koeller KK, Rosenblum RS, Morrison AL. Neoplasms of the spinal cord and filum terminale: radiologic-pathologic correlation. Radiographics. 2000;20:1721-49.

10. Onda K, Tanaka R, Takahashi H, Takeda N, Ikuta F. Cerebral glioblastoma with cerebrospinal fluid dissemination: a clinicopathological study of 14 cases examined by complete autopsy. Neurosurgery. 1989;25:533-40.

11. YungWA, Horten BC, Shapiro WR. Meningeal glimatosis: a review of 12 cases. Ann Neurol. 1980;8:605-8.

12. O’Connell JE. The subaarachnoid dissemination of spinal tumors. J Neurol Neurosurg Psychiatry. 1946;9:55-62.

13. Gunderson LL, Tepper JE. Spinal Cord Tumors. Chapter 30. In: Siker M.L, Bovi J., Alexander B (Eds.). Clinical Radiation Oncology, Philadelphia 2015; pp:532-3.

14. Nakamura M, Ishii K, Watanabe K, et al. Surgical treatment of intramedullary spinal cord tumors: prognosis and complications. Spinal Cord. 2008;46:282-6.

15. Kim WH, Yoon SH, Kim CY, et al. Temozolamide for malignant primary spinal cord glioma: An experience of six cases and a literature review.J Neurooncol. 2011;101:247-54.

16. Bernadine RD. Tumors of the Central Nervous System, Adult gliomas. Jiade J. LUi Luther W. BRADY. Radiation oncology: An Evidence-Based approach 2008;pp:487.

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