Primary spinal glioblastoma is a very rare disease of spinal cord with high morbidity and mortality. In this study, we presented two patients surgically treated for primary spinal glioblastoma. The first case was a 21-year-old male who has a lesion at T9-T10 spinal level in Magnetic resonance imaging (MRI) in which subtotal resection was performed. The second case was a 22-year-old male patient who has a lesion in the spinal canal between the level of C3 andT1 in MRI. The lesion was resected subtotally. The pathological diagnosis was reported as glioblastoma in both cases. Primary spinal glioblastoma is a very rare disease. Because of its clinically and radiologically malignant behavior of prognosis, this disease must be kept in mind in differential diagnosis of cervical-thoracal spinal cord pathologies and early diagnosis and treatment should be started as soon as possible.
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