CONSUMPTION OF GREEN TEA OR ITS DERIVATIVE CATECHIN MAY IMPROVE NEURAL REGENERATION IN A RAT SPINAL CORD INJURY MODEL

Objective: Tea contains antioxidant compounds from the polyphenol group known as catechins. The most abundant of catechins is Epigallocatechin3-gallate (EGCG). Epidemiological studies show that tea has a protective effect against cancer, neuronal damage after transient global ischemia and cardiovascular diseases. This study aimed to investigate a possible neuroprotective effect of EGCG in a rat spinal cord injury (SCI) model. Materials and Methods: The study was performed with 35 Albino-Wistar rats. Rats were divided into five groups: daily consumption group (intraperitoneal given ECGC 1.7 mg/kg/day), treatment groups (intraperitoneal given ECGC 5 mg/kg/day and 10 mg/kg/day), saline group and control group for 14 days prior to trauma. All groups, other than the control group, injured with a pressure of 35 g/cm2 and 1-minute compression. These operations were applied to the spinal cord at level T9-T10. In all groups, nerve samples were taken after 28 days and examined biochemically and histopathologically. Results: In our study, daily consumption ECGC group, 5 mg/kg ECGC group and 10 mg/kg ECGC group statistically significant lower level of lipid peroxidation. Especially daily consumption ECGC group and 5 mg/kg ECGC group were positively decreased histological degeneration and oedema. Histological evaluation, white-grey matter sparing, glial scar formation, protoplasmic astrocytes’ number, cavity size, also had better results in these groups. Conclusion: In this study, it has been shown that catechin group antioxidant substances in tea have a protective effect in neuronal damage such as SCI.

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