The electrophilic carbon atoms of aldehydes can be targets of nucleophilic attack byamines. The end result of this reaction is a compound in which the C=O double bond isreplaced by a C=N double bond. This type of compound is known as a Schiff base.In this study some Schiff bases were synthesized from 2-quinoline aldehyde and someaniline derivatives and the molecules were characterized with spectroscopic methods. ThepKa values of the molecules calculated with potentiometric methods and DFT calculatedmethods. The spectroscopic and the potentiometric results were compared with thecalculated results.