Hülya ÇELİK ONAR, Fatma Ceren ANLAŞ, Hasniye YAŞA, Fulya ÜSTÜN ALKAN, Belma HASDEMİR, Tülay BAKIREL

ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES

This study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin. Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effective cytotoxic potential against CMT-U27 and IC50 concentrations were recorded at 1.952 µM and 54.00 µM, respectively.

Keywords:

Anilide, Semicarbazone, Fatty Acid, Canine mammary tumor,

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