Ganna SYROVA, Valentina PETİUNİNA, Olena SAVELİEVA, Tetyana TİSHAKOVA, Larysa LUKİANOVA

Anti-Inflammatory Effect of Coxibs and their Compositions with Caffeine on the Level of Conjugated Dienes in the Formalin-Induced Edema Model

The development of novel pharmaceutical compositions, which are effective in the treatment of different inflammatory diseases and have a minimum number of side effects is very relevant. The aim of the present study was biochemical confirmation of anti-inflammatory activity of new pharmaceutical compositions comprising coxibs and caffeine. The level of conjugated dienes as primary products of lipid peroxidation has been evaluated in the plasma of rats at the acute inflammation caused by formalin. The white male rats of WAG line were used. The content of conjugated dienes was determined by spectrophotometric method. It was shown that combinations of caffeine and coxibs showed statistical significant decrease in the content of conjugated dienes in the rats’ blood plasma. Caffeine enriched anti-inflammatory action of coxibs effectively.

Keywords:

Celecoxib, rofecoxib, caffeine, conjugated dienes, non-steroidal anti-inflammatory drugs.,

PDF

___

1. Omoigui S. The biochemical origin of pain: the origin of all pain is inflammation and the inflammatory response. Part 2 of 3 – inflammatory profile of pain syndromes. Med. Hypotheses. 2007;69(6):1169-1178. Doi:10.1016/j.mehy.2007.06.033.
2. Aydede M. Defending the IASP definition of pain. The Monist, 2017;100(4):439-464.
3. Jain P, Pandey R, Shukla SS. Inflammation: Natural Resources and Its Applications. SpringerBriefs in Immunology, 2015.
4. Nasonov EL, Lazebnik LB, Belenkov YuN. The use of non-steroidal anti-inflammatory drugs. Clinical guidelines. M: Almaz, 2006.88 p.
5. Meek IL, Van de Laar M. A. F. J., Vonkeman HE. Non-steroidal anti-inflammatory drugs: An overview of cardiovascular risks. Pharmaceuticals (Basel). 2010;3(7):2146-2162. Doi: 10.3390/ph3072146.
6. Bennett JS, Daugherty A., Herrington D., Greenland P., Roberts H., Taubert KA. The use of nonsteroidal anti-inflammatory drugs (NSAIDs): a science advisory from the American Heart Association. Circulation, 2005;111(13):1713-6. doi: 10.1161/01.
7. Nikitenko VV, Borisova EG, Polevaya LP. Results clinical assessment of the application of nonsteroidal anti-inflammatory drugs for pain symptoms occurring after endodontic dental treatment. Bulletin of the Russian Military Medical Academy, 2018;20(1):91-94. Doi: 10.17816/brmma12228.
8. Krasselt M., Baerwald C. Celecoxib for the treatment of musculoskeletal arthritis. Expert Opin Pharmacother, 2019;20(14):1689-1702. doi: 10.1080/14656566.2019.1645123.
9. Pat. 51082 UA, IPC A61K 31/00 A method of potentiating the analgesic action of potassium salt of 2,4-dichlorobenzoic acid / Syrova GO. Publ. 25.06.10, Bul. N 12.
10. Zhuravleva MV, Kukes VG, Prokofiev AB, Serebryanova S.Yu, Goroditskaya GI, Berdnikova NG. Rational use of NSAIDs – balance of efficacy and safety (literature review). International Journal of Applied and Basic Research, 2016;6(4):687-696.
11. Mishchenko N. Movalis in clinical practice: the optimal ratio of efficacy and safety. Health of Ukraine, 2011;(1):34-35.
12. Kristian S., Sajeewane S., Рaul S. Effectiveness and Safety of Celecoxib for the Treatment of Rheumatoid Arthritis. Am Fam Physician, 2018;97(9):573.
13.. Kirane A., Toombs J. E., Ostapoff K., Carbon JG., Zaknoen S., Braunfeld J., Schwarz RE., Burrows FJ., Brekken RA. Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer. Clinical Cancer Research, 2012;18(18):5031-5042. doi: 10.1158/1078-0432.CCR-12-0453.
14. Taranova NA., Govorova LV. Determination of total lipids in lipid extract obtained from blood plasma. Questions honey. chemistry, 1987;2:132-136.
15. 1Wallgren M., Beranova L., Linh Kh., Lidman M., Procek J., Cyprych K., Hof M., Gröbner G. Impact of oxidized phospholipids on the structural and dynamic organization of phospholipid membranes: a combined DSC and solid state NMR study. Faraday Discussions, 2013;161(10):499-513. http://pubs.rsc.org/en/content/articlelanding/2013/fd/c2fd20089a.
16. Thomas M. Bioactive Oxidatively Truncated Phospholipids in Inflammation and Apoptosis: Formation, Targets, and Inactivation. Biochim. Biophys. Acta, 2013;24:56-60.
17. Golovach IYu. An innovative NSAID with gastroprotective properties in rheumatological practice. Ukrainian Rheumatology Journal, 2016;63(1):9-11.
18. Nasonov EL. Analgesic therapy in rheumatology: a journey between Scylla and Charybdis. Clin. pharmacol. and therapy, 2003;12(1):64-69.
19. Lee Y. Effect and treatment of chronic pain in inflammatory arthritis. Cur Rheumatol Rep., 2013;15(1):300.
20. Lain L. Proton pump inhibitor co-therapy with nonsteroidal anti-inflammatory drugs-nice or necessary? Rew Gastroenterol Disord, 2004;4:33-41.
21. Belousov YuB., Moiseev VS. Clinical pharmacology and pharmacotherapy: A guide for physicians. M: Universum Publishing, 1997. 532.
22. Lawrence DR, Benitt PN. Inflammation and non-steroidal anti-inflammatory drugs. Clinical pharmacology: hands. per. from English M: Medicine, 1991. T. 1. P. 485-523.
23. Matuzov SA. Treatment of chronic traumatic osteomyelitis using antioxidants: author. dis. ... Phd. Irkutsk, 1997. 27 p.
24. Koruk ST., Aksoy N., Hamidanoglu M., Karsen H., Unlu S., Bilinc H. The activity of paraoxonase and arylesterase in patients with osteomyelitis. Scandinavian Journal of Clinical and Laboratory Investigation, 2012;72:513-517. http://www. tandfonline.com/toc/iclb20/72/7.
25. Sultonov ShR, Azizov AA, Saburova AM. Dynamics of lipid peroxidation processes and antioxidant defense system in chronic hematogenous osteomyelitis in children. Reports Acad. Sciences Resp. Tajikistan, 2009;52:723-727.
26. Wallgren M., Beranova L., Linh Kh., Lidman M., Procek J., Cyprych K., Hof M., Gröbner G. Impact of oxidized phospholipids on the structural and dynamic organization of phospholipid membranes: a combined DSC and solid state NMR study. Faraday Discussions, 2013;161,10:499-513. http://pubs.rsc.org/en/content/articlelanding/2013/fd/c2fd20089a.
27. Thomas M. Bioactive Oxidatively Truncated Phospholipids in Inflammation and Apoptosis: Formation, Targets, and Inactivation. Biochim. Biophys. Acta, 2013;24:56-60.
28. Bachynsky RO, Vakulenko NV, Boyko EP. Experimental study of the effect of caffeine on the analgesic effect of known nonsteroidal anti-inflammatory drugs of different chemical structure, Zaporozhye medical journal, 2011:13(5):60-62.
29. Syrova GO, Zvyagintseva TV. / XII Congress of the World Federation of Ukrainian Medical Societies: abstracts, Ivano-Frankivsk, Ukraine, 2008: 454.
30. Preclinical studies of drugs: a method. rivers for ed. OV Stefanova. Kyiv, 2001. 527.
31. European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Council of European. Strasbourg, 1986, 123. 51.
32. Modern problems of bioethics / editor-in-chief YuI Kundiev. Kyiv: Akademperiodika, 2009. 278.
33. Stalnaya I. D. Method for determination of diene conjugation of unsaturated higher fatty acids. Modern methods in biochemistry / Ed. VN Orekhovich. M: Medicine, 1972:63-64.

Journal of the Turkish Chemical Society Section A: Chemistry-Cover

Başlangıç: 2014
Yayıncı: Türkiye Kimya Derneği

Arşiv