Edhem ÜNVER, Aytekin ÇIKMAN, Faruk KARAKEÇİLİ

Tükiye, Erzincan ilinde influenza B salgınının klinik ve demografik özellikleri

Amaç: Mevsimsel influenza epidemileri, dünya çapında önemli morbidite ve mortalite nedenidir. Çalışmamızda Türkiye’nin Erzincan ilinde mevsimsel influenza virüslerinin dağılımı ile influenza B salgınının klinik ve demografik özelliklerinin araştırılması amaçlanmıştır.Yöntemler: 2017 bahar döneminde Dünya Sağlık Örgütü ve Sağlık Bakanlığı’nın önerileri doğrultusunda influenza vaka yönetim şemasına uygun olarak, hastanemize başvuran 103 hasta çalışmaya dahil edildi. Özel eküvyon çubukları yardımıyla nazofarengeal sürüntü örnekleri alındı. Influenza A / Influenza B virüslerini tespit etmek için mikroişlemci kontrollü I-CORE® (Akıllı Soğutma / Isıtma Optik Reaksiyonu) modülünü temel alan entegre bir RNA çoğaltma ve algılama cihazı olan Cepheid SmartCycler Sistemi kullanıldı.Bulgular: İnfluenza ön tanısı ile başvuran tüm hastaların 28 (%27,1)’i influenza pozitif bulunurken, 23 (%22.3)’ü Influenza B, 5 (% 4,9)’i Influenza A saptandı. Influenza B pozitif saptanan hastaların 18 (%78)’i bir veya daha fazla kronik hastalığa sahip olduğu saptandı. Hastaların 15 (%65)’i kronik akciğer hastalıklarından birine, 8 (%35)’i kronik kalp hastalıklarından birine, 3 (%13)’ü diabetes mellitus tanısı alan kişilerdi. Influenza B pozitif hastalarında en sık karşılaştığımız semptomlar; myalji, öksürük, ateş ve nefes darlığıydı. Lökopeni ve trombositopeni, lökositozdan daha sık saptandı. Hastaların 7’si yatırılarak takip edildi. Takip edilen dönemde hastaların 3’ü yoğun bakım servisine alındı, bu hastaların 2’si öldü. Diğer hastalar ise şifa ile taburcu edildi.Sonuç: İnfluenza B'nin beklediğimizden daha ciddi seyrettiğini gözlemledik. Bu nedenle, İnfluenza B'ye karşı topluluğun bağışıklık düzeyinin, farklı tipte İnfluenza B alt tiplerini içeren aşılama kampanyalarıyla artırılması gerektiğini düşünüyoruz.

Anahtar Kelimeler:

İnfluenza, İnfluenza B virüsü, Epidemiler, Mevsimsel epidemiler, PCR

Clinical and demographic characteristics of influenza B outbreak in Erzincan province of Turkey

Aim: Seasonal epidemics of influenza are responsible for significant morbidity and mortality worldwide. We aimed to investigate distribution of seasonal influenza viruses, and clinical and demographic characteristics of influenza B epidemics in Erzincan province of Turkey. Methods: A total of 103 patients who presented to our hospital in spring the season in accordance with influenza case management schema in line with the recommendations by the World Health Organization and Ministry of Health were included in this study. Cepheid SmartCycler system, which is an integrated RNA replication and detection device based on microprocessor controlled I-CORE® (Intelligent Cooling / Heating Optical Reaction) module was used in order to detect Influenza A / Influenza B viruses. Results: Influenza was positive in 28 (27.1%) of all patients who presented with suspected Influenza, with 23 (22.3%) being Influenza B and 5 (4.9%) Influenza A. Of patients with positive Influenza B, 18 (78%) had one or more chronic diseases. Of the patients, 15 (65%) were diagnosed with one of the chronic pulmonary disease, 8 (35%) one of the chronic cardiac diseases, and 3 (13%) diabetes mellitus. Leukopenia and thrombocytopenia were more common than leucocytosis. Seven patients were followed-up as inpatients. At the follow-up period, three of the patients were taken to the intensive care unit and 2 of them died. Whereas the remaining patients were discharged with recovery.Conclusion: We observed that, Influenza B progressed more seriously than we expected. For this reason, we think that immunity level of the community against Influenza B should be raised with vaccination campaigns involving different subtypes of Influenza B.

Keywords:

Influenza, Influenza B, Epidemics, Seasonal epidemics, PCR,

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