Kafil AKHTAR, Binjul JUNEJA, Sadaf HAİYAT, Abdul WARİS

Oküler Retinoblastom ve neuroblastoma: Bir sitolojik izlenim

Küçük-yuvarlak-mavi hücreli tümör (SRBCT) veya küçük-yuvarlak hücreli tümör (SRCT), çocuklarda (0-20 yaş) yetişkinlerden daha sık görülen bir malign neoplazm grubudur. Bunlar genellikle küçük yuvarlak hücreli tümörlerin ayırıcı tanısı olarak Ewing sarkoması, periferik nöroektodermal tümör (PNET), rabdomiyosarkom, sinovyal sarkom, non-Hodgkin lenfoma, retinoblastoma, nöroblastoma, hepatoblastoma ve nefroblastom veya Wilms tümörünü içerir. Haematoksilen ve Eosin ile boyanmış kesitler üzerinde mavi leke veren küçük yuvarlak hücrelerden oluşan karakteristik bir görünüme sahiptirler. Bunlar tipik olarak minimal veya hiç farklılaşma ile ilkel hücrelerden oluşan farklılaşmamış hücreleri temsil ederler. Bu kanserlerin doğru teşhisi önemlidir çünkü tedavi seçenekleri, tedaviye yanıtlar ve prognozlar tanıya bağlı olarak geniş çapta değişir. Bu tümörlerin önemli bir modalitesi olarak ince iğne aspirasyon sitolojisi (FNAC) ile multimodal bir yaklaşım uygulanmaktadır. Olgu serimizde ince iğne aspirasyonu tanısı konan ve daha sonra histopatolojik incelemede doğrulanan oküler retinoblastom ve nöroblastoma tartışılacaktır. Bu çalışma, klinik özelliklerin ve görüntülemenin sonuçsuz olduğu tespit edilen destekleyici bir tanı aracı olarak intraoküler FNAC'ın kullanımını ve güvenliğini belirlemek için yapılmıştır.

Anahtar Kelimeler:

İnce iğne aspirasyon sitolojisi, İmmünhistokimya, Malign küçük yuvarlak hücreli tümörler, Nöroblastoma, Oküler, Retinoblastom

Ocular retinoblastoma and neuroblastoma: A cytological impression

Small-round-blue-cell tumor (SRBCT) or a small-round-cell tumour (SRCT) is a group of malignant neoplasms which are seen more often in children (0-20 years-old) than in adults. They generally include Ewing's sarcoma, peripheral neuroectodermal tumor (PNET), rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, retinoblastoma, neuroblastoma, hepatoblastoma, and nephroblastoma or Wilms’ tumor as differential diagnoses of small round cell tumors. They have a characteristic appearance consisting of small round cells that stain blue on Haematoxylin and Eosin stained sections. They typically represent undifferentiated cells which are composed of primitive cells with minimal or no differentiation. Accurate diagnosis of these cancers is essential because the treatment options, responses to therapy and prognoses vary widely depending on the diagnosis. A multimodal approach is employed with fine needle aspiration cytology (FNAC) as an important modality of diagnosis for these tumors. We will discuss ocular retinoblastoma and neuroblastoma in our case series which were diagnosed on fine needle aspiration itself and were later confirmed on histopathological examination. This study was also undertaken to determine the utility and safety of intraocular FNAC as a supportive diagnostic tool where clinical features and imaging were found to be inconclusive.

Keywords:

Fine needle aspiration cytology, Immunohistochemistry, Malignant small round cell tumors, Neuroblastoma, Ocular, Retinoblastoma,

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