Obstrüktif uyku apne sendromu (OUAS)’na bağlı hipertansiyon: Patofizyolojisi ve tedavi yaklaşımlarına dair bir derleme

Obstruktif uyku apne sendromu (OUAS), hipertansiyon da dahil olmak üzere kardiyovasküler hastalıklarla ilişkisi olan yaygın bir uyku bozukluğudur. OUAS ve hipertansiyon arasındaki ilişkiyi destekleyen birçok kanıt mevcuttur; ancak bu kompleks sebep-sonuç etkileşiminin altında yatan kesin mekanizma halen net değildir. OUAS ile alakalı hipertansiyonun değişken yapısı, kalp ve beyinin de dahil olduğu hedef organ hasarı ile yakından ilişkilidir. Bu derlemede, OUAS ile ilişkili hipertansiyonun etyolojik faktörleri, klinik tipleri, olası patofizyolojik mekanizmaları, tanı yöntemleri ve güncel tedavi yaklaşımları güncel literatür ışığında tartışılmıştır.

Anahtar Kelimeler:

Obstruktif uyku apne sendromu, Hipertansiyon, PAP, Üst havayolu cerrahisi

Obstructive sleep apnea syndrome (OSAS) related hypertension: A review of pathophysiology and potential therapeutic approaches

Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder related with cardiovascular diseases, including hypertension. There are lots of evidence supporting the relationship between OSAS and hypertension, modulated by multiple factors, but the exact mechanisms underlying this complex cause and effect relationship remain unclear. The alternating pattern of OSAS-related hypertension is closely related with target organ damage, especially in the heart and brain. In this review, the etiological factors, clinical types, probable pathophysiologic mechanisms, diagnostic methods, and current therapeutic approaches to OSAS-related hypertension is discussed in the light of current literature.

Keywords:

Obstructive Sleep Apnea Syndrome, Hypertension, CPAP, Upper airway surgery,

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