Fatma DEMİRBAŞ, Gönül DİNLER ÇALTEPE, Atakan COMBA, Hasan ABBASGULİYEV, Ayhan Gazi KALAYCI

Obez çocuklarda alkolsüz yağlı karaciğer hastalığı ile serum c-peptit, c-peptit-glikoz ve c-peptit-HbA1C oranı arasındaki ilişkinin değerlendirilmesi

Amaç: Obeziteye bağlı görülen metabolik sendrom, insulin direnci ve non-alkolik yağlı karaciğer hastalığı (NAYKH)gibi komplikasyonlar çocukluk çağında da sıklığı giderek artmaktadır. Bu çalışmanın amacı, NAYKH ile ilişkili obez çocuklarda açlık c-peptit, c-peptit-glukoz ve c-peptit-HbA1C oranlarını araştırmaktır. Yöntemler: Bu vaka-kontrol çalışması Ağustos-Kasım 2018 arasında gerçekleştirildi. Çalışmaya 40'ı NAYKH ile ilişkili ve 20'si NAYKH olmayan toplam 60 obez çocuk alındı. VKİ> 2 z-skoru olan hastalar obez olarak kabul edildi. NAYKH’nin ultrasonografik özellikleri, karaciğer kontrastı ve ekojenitede parlaklık olarak tanımlandı. Hastaların serum açlık c-peptit düzeyleri karşılaştırıldı. Bulgular: Çalışmaya dahil edilen 60 hastanın 37'si (%61,7) erkekti ve ortalama yaş 11,9 (2,9) yıldı. NAYKH'li hastalarda ortalama ALT, ağırlık, BMI, bel çevresi, bel çevresi-boy oranı, serum c-peptit, açlık c-peptit-glikoz oranı, açlık c-peptit-HbA1C oranı ve insülin seviyeleri, NAYKH olmayan obez çocuklara göre anlamlı olarak daha yüksekti. (her biri için P

Anahtar Kelimeler:

çocukluk çağı, c-peptit, c-peptit-glikoz oranı, c-peptit-HbA1C oranı, non-alkolik yağlı karaciğer hastalığı, obezite

Evaluation of the relationship between non-alcoholic fatty liver disease and serum c-peptide, c-peptide to glucose and c-peptide to HbA1C ratio in obese children

Aim: Obesity-related complications such as metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease (NAFLD) have increased in childhood. The aim of this study is to investigate the fasting c-peptide, c-peptide to glucose and c-peptide to HbA1C ratios in obese children with NAFLD. Methods: This case-control study was conducted from August through November 2018. A total of 60 obese children, 40 with and 20 without NAFLD, were included in the study. Patients with BMI > 2 z-score were considered obese. The ultrasonographic characteristics of NAFLD were identified with liver contrast and brightness in echogenicity. Serum fasting c-peptide levels of patients were compared. Results: Of the 60 patients included in the study, 37 (61.7%) were male and the mean age was 11.9 (2.9) years. The mean ALT, weight BMI, waist circumference, waist to height ratio, serum c-peptide, fasting c-peptide to glucose ratio, fasting c-peptide to HbA1C ratio and insulin levels were considerably higher in patients with NAFLD (P

Keywords:

Childhood, C-peptide, c-peptide-to-glucose ratio, c-peptide-to-HbA1C ratio, Non-alcoholic fatty liver disease, , obesity,

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