Obez çocuk ve adölesanlarda metabolic sendrom ve non-alkolik karaciğer yağlanmasını öngörmede yeni belirteçler: Plazma aterojenik indeks ve monosit / yüksek dansiteli lipoprotein kolesterol oranı

Amaç: Bu çalışmada obezitesi olan çocuk ve adölesan hastalarda plazma aterojenik indeks (PAİ) ve monosit / HDL oranı (MHO) ile metabolik sendrom (MS), insülin direnci (İD), bel çevresi (BÇ) ve non-alkolik karaciğer yağlanması (NAKY) arasındaki ilişkinin araştırılması amaçlanmıştır. Yöntemler: Çalışma kesitsel olup, 172 obez çocuk hasta ile 63 sağlıklı kontrol hastası içermekteydi. Antropometrik ve biyokimyasal parametreler [ağırlık, boy, beden kitle indeksi (BKİ) standart deviasyon skoru (SDS), BÇ, hemogram, aspartat transaminaz (AST), alanin transaminaz (ALT), insulin, glukoz, total kolesterol (TC), yüksek-dansiteli lipoprotein kolesterol (HDL-C), trigliserid (TG), düşük-dansiteli lipoprotein kolesterol (LDL-C), HOMA-IR, PAİ ve MHO ] değerlendirildi. Plazma aterojenik indeks; düşük (0,21) risk diye üç gruba ayrıldı. Metabolik sendrom tanımı Uluslararası Diyabet Fedarasyonuna göre yapıldı. Bulgular: Obez hasta grubunda BKİ SDS, BÇ, HOMA-IR, TC, TG, LDL-C, AST, ALT, PAİ değeri ve MHO anlamlı ölçüde yüksek saptandı (her biri için P

Anahtar Kelimeler:

plazma aterojenik indeks, monosit HDL oranı, obezite, metabolik sendrom, çocuklar

Novel markers in predicting non-alcoholic liver fatty and metabolic syndrome in obese children and adolescents: Atherogenic index of plasma and monocyte / high-density lipoprotein cholesterol ratio

Aim: The aim of this study is to investigate the relationship between metabolic syndrome (MetS), insulin resistance, waist circumference (WC) and non-alcoholic fatty liver disease (NAFLD) with atherogenic index of plasma (AIP) and monocyte/ high-density lipoprotein cholesterol ratio (MHR) among obese children and adolescents. Methods: The cross-sectional study consisted of 172 obese and 63 healthy children. Anthropometric and biochemical parameters [Weight, height and BMI SDS, WC, Complete blood count, aspartate-aminotransferase (AST), alanine-aminotransferase (ALT), insulin, glucose, total cholesterol (TC), high-density lipoprotein (HDL-C), triglyceride (TG) and low-density lipoprotein (LDL-C), homeostasis model assessment-insulin resistance (HOMA-IR), AIP, MHR] were assessed. The AIP was classified into three groups: Low (0.21) risk. The MetS definition proposed by the International Diabetes Federation was adopted. Results: BMI SDS, WC, HOMA-IR, TC, TG, LDL-C, AST, ALT, AIP, and MHR parameters were significantly higher among the obesity group (P

Keywords:

atherogenic index of plasma monocyte to HDL cholesterol ratio, , obesity, metabolic syndrome, children,

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