Mohammad Mehdi Soltan Dallal, Mohammad Khalifeh-Gholi, Sara Sharifi Yazdi, Fariborz MEHRANİ, Azim Hadayatpour, Mohammad Kazem Sharifi Yazdi

İran, Tahran’daki hastalarda izole edilen Klebsiella suşunun antimikrobiyal direnç paterni

Amaç: Klinik örneklerin çoğu Klebsiella türleri ile enfekte olabilmektedir. Ayrıca ilaca dirençli Klebsiella insidansı artmaktadır, bu nedenle antibiyotik reçete edilmeden önce ilaç direnci duyarlılık testi gerekli görünmektedir. Bu araştırmanın amacı Klebsiella türlerinin antimikrobiyal direncini klinik olarak belirlemektir.Yöntemler: Bu araştırma, 2016 ve 2017 yılları arasında hastanede yatan hastalardan toplanan 300 Klebsiella örneği üzerinde gerçekleştirilmiştir. Tanımlama standart yönteme göre gerçekleştirilmiş ve ilaç duyarlılık testi Kirby-Bauer yöntemi ile belirlenmiştir.Bulgular: İzole Klebsiella türlerinin sıklık oranları: pnömoni (% 94), oksitoka (% 4), ozaenae (% 1) ve rinososikromatis (% 1). Sıklık sırasına göre toplanan örnekler: idrar, balgam, vajina, skar, dışkı ve kan idi. Rezistans yüzdesi şöyledir: Ampisilin (%97), amoksilin (%97), cefalotin (%39), gentamisin (%30), kolistin (%55), nalidiksik asit (%2), kloramfenikol (%26), kanamisin (%17), tetrasiklin (%28), nitrofurantoin (%44), seftazidim (%2) ve amikasin (%0).Sonuç: Test edilen Klebsiella türlerinde en düşük direnç oranı Amikasin ile elde edilmiştir ve en etkili antibiyotik olarak önerilebilir.

Anahtar Kelimeler:

Klebsiella, Enfeksiyon, Antibiyotik direnci

Antimicrobial resistance pattern of Klebsiella spp isolated from patients in Tehran, Iran

Aim: The majority of clinical specimens infected can be by Klebsiella species. Furthermore the incidence of drug resistant Klebsiella is increasing, therefore drug resistance sensitivity test it seems necessary before prescribing antibiotics. The aim of this research was to determine the pattern of antimicrobial resistance of Klebsiella species from clinical.Methods: The present research was performed on 300 specimens of Klebsiella collected from hospitalized patients between 2016 and 2017. Identification was carried out according to standard procedure, and drug sensitivity test was determined by Kirby-Bauer method.Results: The frequency rates of the isolated Klebsiella species were: pneumonia (94%), oxytoca (4%), ozaenae (1%), and rhinoscleromatis (1%). The collected samples in order of frequency were: urine, sputum, vagina, scar, stool, and blood respectively. The percentage rates of resistance were as follows: Ampicillin (97%), amoxycillin (97%), cephalothin (39%), gentamicin (30%), colistin (55%), nalidixic acid (2%), chloramphenicol (26%), kanamycin (17%), tetracycline (28%), nitrofurantoin (44%), ceftazidime (2%), and amikacin (0%).Conclusion: The lowest resistance rate obtained with amikacin in all tested Klebsiella; which can be recommended as the most effective antibiotic.

Keywords:

Klebsiella, Infection, Antibiotic resistance,

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