Ahmet Serhat EKİNCİ, Keriman ÖZADALI-SARI, Jan MONCOL, Vagolu Siva KRISHNA, Dharmarajan SRIRAM

5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercularagents

This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosisH37Rv strain bymicroplate alamar blue assay. Also the crystal structures of the compounds (2aand 2c) were determined by the single-crystal X-ray diffraction study.Among the target compounds, 2-(4-ethoxyphenyl)-5-methyl-3-(phenylamino)thiazolidin-4-one (2g) was promising with a minimum inhibitory concentrationof 12.5 μg/mL against M. tuberculosis.Based on the preliminary results, 2gwas considered as a leadcompoundfor further optimizationof antimycobacterialactivity.

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