Aytekin ALÇELİK, Abdulkadir KOÇER, Emel KOÇER, Gülşen KOCAMAN

A Study of Leukocyte and Platelet Activity in Patients with Suicide Attempt Related to Acute Stres Reaction

Amaç: Akut stres reaksiyonu (ASR) sıklıkla depresyonla birliktegörülür ve stresle ilişkili hormonlar trombosit birikimiyle ilişkiliarteriyel trombozda önemli rol oynarlar. Bilgimize göre ASRile ilişkili bir intihar girişimi sonrasında lökosit ve trombositsayımını değerlendiren çalışma yoktur. Yöntem: Bu çalışmada kan lökosit, trombosit ve ortalamatrombosit hacim (MPV) düzeyleri incelendi. İlave olarak, buparametreleri etkileyen etmenler değerlendirildi. Acile başvuran ve intihar girişimi sonrasında aynı psikiyatrist tarafındandeğerlendirilen hastalara ait veriler toplandı. Aynı bölgedeyaşayan sağlıklı örneklem grubu kontrol grubu olarak kabuledildi. Vaka-kontrol çalışması olarak dizayn edilen bu çalışmada 30 intihar girişimi vakası ve yaş ve cinsiyet olarak uygun 33kontrol vakası analize tabi tutuldu. Bulgular: İntiharla ilişkili ASR tanısı olan 30 kişinin kontrollerle karşılaştırılmasında kan sonuçları artmış lökosit düzeyisaptanırken trombosit sayısı ve MPV düzeyleri benzer bulundu. Takipte, trombosit düzeyi hasta grubunda daha düşükdüzeylerde bulundu (p=0.001) ve bu düşüklük intihar amaçlıantidepresan kullanımı ile ilişkiliydi (p=0.003).Sonuç: ASR sonrasında trombosit sayısı veya MPV düzeyiartmadı, fakat lökosit sayısında artış gözlemlendi. İlaveten,çalışmamız antidepresan ilaçlarla ilişkili anti-trombosit etkininvarlığını da desteklemekteydi.

Akut stres reaksiyonu ile ilişkili olarak intihar giri- şiminde bulunan hastalarda lökosit ve trombosit aktiviteleri üzerine bir çalışma

Aim: Acute stress reaction (ASR) is often seen with depression,and stress-related hormones may play an important role inacute arterial thrombosis by increasing platelet aggregation. Tothe best of our knowledge, no study has examined leukocyteand platelet counts following a suicide attempt with ASR.Method: The present study examined blood leukocyte, plateletand mean platelet volume (MPV) levels. In addition, weexamined the factors affecting these parameters. Data forpatients who were admitted to the emergency room andevaluated by same psychiatrist after a suicide attempt wereobtained from the health registries. Controls were selectedfrom all residents living in the same area. Using a case- control design, we examined 30 suicide cases and 33 controlsmatched for gender and age.Results: The 30 subjects diagnosed with ASR related suicideshowed increased white blood cell counts but similar plateletcounts and mean platelet volume compared with controls. Atfollow-up, the platelet count was lower in patients than incontrols (p= 0.001), which was related to suicide attempts byusing anti-depressants (p= 0.003).Conclusion: ASR did not increase platelet count or MPV, butwe found an increase in leukocyte counts following ASR.Additionally, our study supported the antiplatelet effect ofantidepressant medications.

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