İyileşmiş COVID-19 hastalarının endotel disfonksiyonu ve inflamasyonun değerlendirilmesi

Amaç: Çalışmamızda COVİD-19 enfeksiyonu geçirme hikayesi olan genç kişilerde endoteyal fonksiyonunu ve inflamasyon belirteci olarak kabul edilen hemogram parametrelerini değerlendirmeyi amaçladık. Yöntemler: Bu prospektif çalışmaya 109 iyileşen COVID-19 hastası ve 50 sağlıklı kontrol olgusu alındı. Grupların demografik özellikleri, laboratuvar değerleri ve akım aracılı vazodilatasyon testi (FMD) sonuçları karşılaştırılmıştır. Bulgular: Grupların demografik verileri ve biyokimya parametreleri benzerdi. Hesaplanan FMD değerleri COVID-19 geçiren hasta grubunda kontrol grubuna kıyasla anlamlı derecede daha düşüktü (8,66±3,31 ve 11,69±3,01; p= 0,001). Nötrofil/lenfosit oranı (NLR) ve Platelet/Lenfosit oranı (PLR) arasında gruplar arasında fark yokken, sistemik immün-inflamasyon indeksi (Sİİ) COVID-19 enfeksiyonu geçirmiş hasta grubunda daha yüksek saptandı (p = 0.02). Spearman korelasyon analizinde FMD ve SII arasında düşük orta derecede korelasyon saptandı (r=0.35, p=0.002). Sonuç: COVID-19 sonrası uzun vadede kardiyovasküler riskleri değerlendirmek amaçlı erken dönemde FMD ölçümü ve SII faydalı olabilecek basit, kolay ulaşılabilir parametrelerdir. Bu konu hakkında daha geniş çaplı ve çok merkezli çalışmalara ihtiyaç vardır.

Anahtar Kelimeler:

endotel disfonksiyonu, Covid-19, inflamasyon

Evaluation of endothelial dysfunction and inflammation in recovered COVID-19 patients

Aim: In our study, we aimed to evaluate the endothelial functions and hemogram parameters, which are considered as inflammation markers, in young people with a history of COVID-19 infection. Methods: This prospective study included 109 recovered COVID-19 patients and 50 healthy controls. Demographic characteristics, laboratory values and flow-mediated vasodilation test (FMD) results of the groups were compared. Results: Demographic and biochemistry parameters of the groups were similar. The calculated FMD values were significantly lower in the recovered COVID-19 patient group compared to the control group (8.66±3.31 vs 11.69±3.01; p= 0.001). While there was no difference between the groups in terms of neutrophil/lymphocyte ratio (NLR) and Platelet/Lymphocyte ratio (PLR), systemic immune-inflammation index (SII) was found to be higher in the patient group with recovered COVID-19 patients (p = 0.02). In correlation analysis, there was a low moderate negative correlation between FMD and SII (r = -0.35, p=0.002). Conclusion: FMD measurement and SII are simple, easily accessible parameters that can be useful in the early period to evaluate cardiovascular risks in the long term after COVID-19. There is a need for larger and multicenter studies on this subject.

Keywords:

endothelial dysfunction, Covid-19, inflammation,

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