In this report, it is aimed to notify the neuromuscular involvement due to hypothyroidism in a Pekingese mix breed dog. Material and Method: The case consisted of a 7-year-old Pekingese mix breed dog who came to the clinic with a history of paralysis of the left side of his body. Biochemical and haematological examinations were performed. Brain MRI was performed for neurological findings. Hematologic examination revealed neutrophilia, biochemical examination revealed increased creatine kinase (CK) activity and decreased total T4 (