Ahmet BİLGİ, Abdül Hamid GÜLER, Mehmet KULHAN, Mete Can ATEŞ, Havva Hande KESER ŞAHİN, Cetin CELİK

The effect of myometrial invasion and histological grade on lymph node metastasis in patient with early stage endometrium cancer

Aim: Early detection of endometrial cancer is important for the prognosis of the disease. In our study, the effect of myometrial invasion and histological grade on lymph node metastasis was investigated in patient with early stage endometrium cancer . Material and Method: A total of 249 patients from the last 10 years who underwent systemic lymphadenectomy for staging in our hospital were retrospectively examined. The pathologies of these patients were limited to the uterine corpus. The effect of histological grade of tumor and myometrial invasion on lymph node metastasis was evaluated statistically. Results: The average lymph node collected from patients was 27.7 (11-78). Lymph node metastasis was detected in 4.1% of patients with histological grade 1-2 and

Keywords:

Endometrium cancer, Lymph Node Metastasis, Staging, Myometrial invasion,

PDF

___

Zengin M, Eryol M, Aydemir Akkaya M, Devrim T, Yalçın S, Özkan ZS. Did the terminology of endometrial intraepithelial neoplasia resolve the chaos in the classification of endometrial hyperplasia? a 8-year retrospective study. Anatolian Curr Med J 2020; 2; 129-35.
Njoku K, Abiola J, Russell J, Crosbie EJ. Endometrial cancer prevention in high-risk women. Best practice & research Clinical Obstetrics & Gynaecology 2020; 65: 66-78.
Braun MM, Overbeek-Wager E, Grumbo RJ. Diagnosis and management of endometrial cancer. Am Fam Physician 2016; 93: 468-74.
Chan JK, Cheung MK, Huh WK, et al. Therapeutic role of lymph node resection in endometrioid corpus cancer: a study of 12,333 patients. Cancer 2006; 107: 1823-30.
May K, Bryant A, Dickinson HO, Kehoe S, Morrison J. Lymphadenectomy for the management of endometrial cancer. Cochrane Database Syst Rev 2010; 1: CD007585.
Al Hilli MM, Podratz KC, Dowdy SC, et al. Preoperative biopsy and intraoperative tumor diameter predict lymph node dissemination in endometrial cancer. Gynecol Oncol 2013; 128: 294-9.
Kang S, Todo Y, Odagiri T, et al. A low-risk group for lymph node metastasis is accurately identified by Korean gynecologic oncology group criteria in two Japanese cohorts with endometrial cancer. Gynecol Oncol 2013; 129: 33-7.
Creasman WT. The current status of lymphadenectomy in the management of endometrial cancer. Women's Health (London, England) 2011; 7: 33-5.
Panici PB, Basile S, Maneschi F, et al. Systematic pelvic lymphadenectomy vs no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. JNCI: J National Cancer Institute 2008; 100: 1707-16.
Amant F, Neven P, Vergote I. Lymphadenectomy in endometrial cancer. The Lancet 2009; 373: 1169-70.
Carlson JW, Kauderer J, Hutson A, et al. GOG 244-The lymphedema and gynecologic cancer (LEG) study: Incidence and risk factors in newly diagnosed patients. Gynecol Oncol 2020; 156: 467-74.
Soliman PT, Frumovitz M, Spannuth W, et al. Lymphadenectomy during endometrial cancer staging: practice patterns among gynecologic oncologists. Gynecol Oncol 2010; 119: 291-4.
Mariani A, Webb MJ, Keeney GL, Haddock MG, Calori G, Podratz KC. Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary? Am J Obstet Gynecol 2000; 182: 1506-19.
Convery PA, Cantrell LA, Di Santo N, et al. Retrospective review of an intraoperative algorithm to predict lymph node metastasis in low-grade endometrial adenocarcinoma. Gynecol Oncol 2011; 123: 65-70.
Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer: a Gynecologic Oncology Group study. Cancer 1987; 60: 2035-41.
Milam MR, Java J, Walker JL, et al. Nodal metastasis risk in endometrioid endometrial cancer. Obstet Gynecol 2012; 119: 286.
Shah C, Johnson EB, Everett E, et al. Does size matter? Tumor size and morphology as predictors of nodal status and recurrence in endometrial cancer. Gynecol Oncol 2005; 99: 564-70.
Kadar N, Malfetano JH, Homesley HD. Determinants of survival of surgically staged patients with endometrial carcinoma histologically confined to the uterus: implications for therapy. Obstet Gynecol 1992; 80: 655-9.
Chi D, Barakat R, Palayekar M, et al. The incidence of pelvic lymph node metastasis by FiGO staging for patients with adequately surgically staged endometrial adenocarcinoma of endometrioid histology. Int J Gynecol Cancer 2008; 18: 2.
Kaku T, Tsuruchi N, Tsukamoto N, Hirakawa T, Kamura T, Nakano H. Reassessment of myometrial invasion in endometrial carcinoma. Obstet Gynecol 1994; 84: 979-82.
Jantarasaengaram S, Praditphol N, Tansathit T, Vipupinyo C, Vairojanavong K. Three-dimensional ultrasound with volume contrast imaging for preoperative assessment of myometrial invasion and cervical involvement in women with endometrial cancer. Ultrasound in obstetrics & gynecology : the official J Int Soc Ultrasound Obstet Gynecol 2014; 43: 569-74.
Soliman PT, Frumovitz M, Spannuth W, et al. Lymphadenectomy during endometrial cancer staging: practice patterns among gynecologic oncologists. Gynecol Oncol 2010; 119: 291-4.
Benedetti Panici P, Basile S, et al. Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J National Cancer Institute 2008; 100: 1707-16.
Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer 1987; 60: 2035-41.