Farklı ağırlıktaki bireylerde intragastrik botulinum toksin enjeksiyonu sonrası kilo kaybı

Amaç: İntragastrik Botulinum toksin A enjeksiyonunun, kilo kaybını indüklediği ve asetilkolin aracılı gastrik kasılmaların inhibisyonu sonucu gastrik motiliteyi yavaşlattığı gösterilmiştir. Bu çalışmanın amacı, obez hastalarda intragastrik botulinum toksin A enjeksiyonunun endoskopik intragastrik enjeksiyonlarının kilo kaybı üzerine etkilerini gözlemlemektir.Gereç ve Yöntem: Toplam 400 U intragastrik botulinum toksin A enjeksiyonu endoskopik olarak midenin antrum, korpus ve fundus bölgelerine enjekte edildi. Vücut kitle indeksi değerlerine göre alt gruplara ayrılan 102 hastanın takip sonuçları ve kilo verme durumları değerlendirildi. Kilo kaybı verileri, birbirini izleyen üç ay boyunca aylık takip vizitlerinde kaydedildi.Bulgular: Üçüncü ayın sonunda tüm hastaların vücut ağırlığında azalma gözlendi ve toplam ortalama kilo kaybı oranı %4,76-19,47 arasında değişti. Ortalama toplam vücut ağırlığı kaybı yüzdeleri Sınıf II ve III obez bireylerde normal ve aşırı kilolu ve Sınıf I obez bireylere göre anlamlı olarak daha yüksekti. Gastrointestinal yan etkiler hastaların sadece beşinde (%4,9) gözlendi.Sonuç: 400 U’luk dozla intragastrik botulinum toksini enjeksiyonu uygulaması, farklı vücut kitle indekslerindeki bireylerde kilo kaybı amacıyla kullanımı uygun bir yöntemdir.

Anahtar Kelimeler:

Botulinum toksini, botulinum toksin enjeksiyonu, obezite, kilo kaybı

Weight loss after intragastric botulinum toxin injection in different weight individuals

Background: Intragastric injection of Botulinum toxin A has been shown to induce weight loss, slowering gastric motility as a result of inhibition of the acetylcholine-mediated gastric contractions. The aim of this study was to observe the effects of endoscopic intragastric injections of intragastric injection of botulinum toxin A in obese patients. Material and Method: A total dose of 400 U intragastric injection of botulinum toxin A was injected endoscopically into the antrum, corpus and fundus regions of the stomach. The follow-up results of 102 patients sub-grouped according to body mass indices values and evaluated the weight loss status were evaluated. Weight loss data was collected on the monthly follow-up visits for three consecutive months.Results: At the end of the third month, all subjects lost body weight, with a mean total weight loss ratio ranging between 4.76-19.47%. Mean total body weight loss percentages were significantly higher in Class II and III obese subjects compared to the normal- and over-weight and Class I obese individuals. Gastrointestinal adverse effects were observed in only five (4.9%) of the patients. Conclusion: Intragastric injection of botulinum toxin A administration with a dose of 400 U is a convenient method for weight loss for the individuals of different body mass indices.

Keywords:

botulinum toxin, botulinum toxin injection, obesity, weight loss,

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