Predicting vitamin D deficiency through parathormone in the children of a small city located in the warm climate belt of northern hemisphere

ÖZ Amaç: Bu çalışmanın amacı bir grup sağlıklı çocukta parathormon (PTH), kalsiyum (Ca), fosfor (P), D vitamini düzeylerini ortaya koymak ve “D vitamini eksikliği” ile “yetersizliği” tanıları için düzey saptamaktır. Yöntem: Çalışmaya bilinen kronik sağlık sorunu olmayan 543 çocuk katıldı. PTH, Ca, P, 25(OH)D düzeyleri, kan örneğinin alındığı mevsim, yaş, cinsiyet ve sağlık durumuna ait veriler hastane kayıt sisteminden geriye dönük olarak elde edildi. Değişkenler arasındaki ilişkiler metinde ayrıntılı olarak tanımlanan istatistiksel yöntemlerle değerlendirildi. Bulgular: PTH yükselmesini tetikleyen en düşük PTH değeri 13.6 ng/ml olarak saptandı. Farklı yaş grupları için 25(OH)D düzeyi persentil değerleri hesaplandı. Yaş, PTH ve mevsimin D vitamini düzeylerine katkısı olduğu lojistik regresyon analizleri ile gösterildi. Sonuç: Yaşanılan yerin rakımı ve enlemi Güneş’in Zenith açısını etkilediğinden D vitamini durumunda önemli bir değişkendir. Destek ve tedavi yaklaşımında yaş, cinsiyet ve mevsimler dikkate alınmalıdır. Anahtar sözcükler: D vitamini eksikliği, 25(OH)D, PTH, enlem, çocuk ABSTRACT Aim: The aim of this study is to analyse the serum levels of parathormone (PTH), calcium (Ca), phosphorus (P), vitamin D and define a cut off value for vitamin D deficiency and insufficiency in a sample of healthy children. Methods: A total of 543 healthy children enrolled to this study. The data of PTH, Ca, P, 25(OH)D levels, season of blood sample collection, age, sex and health status were collected from the hospital record system retrospectively. The relationships between these variables were defined by statistical analyses and explained in detail in the text. Results: The inflection point that triggered PTH rise was 13.6 ng/ml. The percentile values of 25(OH)D for different age groups were reported. Logistic regression analyses pointed that age, PTH and seasons contributed to vitamin D status. Conclusion: The habitat is a significant variable for vitamin D status because altitude and latitude affect solar Zenith angle. Age, gender and seasonal variations must be taken in consideration when recommending supplementation. Keywords: Vitamin D deficiency, 25 (OH)D, PTH, latitude, child

Keywords:

vitamin D deficiency, , 25(OH)D, , PTH latitude, child,

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