Abdullah DURHAN, Koray KOŞMAZ, Abdullah ŞENLİKCİ, Ender ERGÜDER, Marlen SÜLEYMAN, Mehmet Esat DUYMUŞ, Yusuf Murat BAĞ, Mevlüt Recep PEKCİCİ, Mehmet ŞENEŞ, İlknur ALKAN KUŞABBİ, Eylem Pınar ESER, Sema HÜCÜMENOĞLU

Does red ginseng ameliorate liver damage caused by obstructive jaundice? : an experimental study

Aim: This experimental study aimed to evaluate the hepatoprotective effect on obstructive jaundice (OJ) of oral red ginseng (RG) extract, which is known to have anti-inflammatory and antioxidant properties. Methods: The rats were randomly separated into 3 groups of 10 rats: the sham group, the control group, and the treatment group. In Group 1 (sham), the common bile duct (CBD) was identified but no ligation or transection was performed. In Group 2 (control), the CBD was identified and ligation and transection were performed, but no treatment was given. In Group 3 (RG group), CBD ligation and transection were performed, then RG extract was administered via an orogastric tube at a dose of 100 mg/ kg/day for 10 days. After 10 days, blood samples were taken for biochemical analysis, and liver tissue samples for biochemical and histopathological analysis. Results: Significantly higher serum albumin levels and lower serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in the RG group than in the control group (p = 0.028, p = 0.001 and p = 0.034, respectively). In the oxidative stress parameters, malondialdehyde (MDA) levels and catalase (CAT) levels were significantly different between the RG group and control group (p = <0.001 for each). Total sulfhydryl (T-SH) was not at a statistically significant level, although it was high and approached the value of the sham group ( p = 0.076). In the histopathological evaluation, the RG group had statistically significantly lower scores in all parameters compared to the control group (p<0.05). Conclusion: The results of this study showed that RG has a strong hepatoprotective effect as a result of its anti-inflammatory and antioxidant properties.

Keywords:

Red ginseng, obstructive jaundice, anti-inflammatory properties, antioxidant properties, hepatoprotective effects,

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