Our convalescent plasma experiences in COVID-19 patients hospitalized in the intensive care unit
Objective: Despite vaccine and drug studies, convalescent plasma (CP) therapy remains an alternative treatment for coronavirus disease 2019 (COVID-19). In this study, we aimed to reveal the efficacy of CP therapy on mortality and the factors affecting it for the patients diagnosed with COVID-19 and acute respiratory distress syndrome (ARDS) which were followed in our intensive care unit (ICU).
Material and Method: The data (demographic characteristics, the amount of CP used, PaO2/FiO2, leukocyte, neutrophil, lymphocyte, D-Dimer, C-reactive protein (CRP), procalcitonin, ferritin values, and the clinical findings) of the patients who were hospitalized in the ICU with the diagnosis of COVID-19 and received CP treatment between 20 March and 20 October 2020 were analyzed retrospectively. Data of deceased patients (n=29) and survivors (n=50) were compared with each other and logistic regression analysis was performed to investigate the relationship with mortality.
Results: 79 patients who received 166 units of CP therapy after a mean of 13.45±3.6 days symptom onset, were identified. 96.2% of the patients had at least one concomitant disease. Mortality was observed in 29 (36.7%) of the patients. Mortality (5.1%) was less common in those receiving CP therapy within the first 14 days after the onset of symptoms. Patient age (p=0.041), neutrophil/lymphocyte ratio (p=0.004), CRP values (p=0.002), the number of comorbidities (p
Keywords:
Convalescent (immune) plasma, COVID-19, Intensive care unit, SARS-Cov-2,
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- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 2018
- Yayıncı: MediHealth Academy Yayıncılık
Sayıdaki Diğer Makaleler
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Haluk Tarık KANİ, Çağlayan KEKLİKKIRAN, İlkay ERGENÇ, Yusuf YILMAZ
Hatice Şeyma AKÇA, Abdullah ALGIN, Serdar ÖZDEMİR, Burcu YILMAZ, İbrahim ALTUNOK
Suat BENEK, Şevki PEDÜK, Mehmet ZENGIN
Kubilay SARIKAYA, Çağri ŞENOCAK, Muhammed Arif İBİŞ, Fahri Erkan SADİOĞLU, Mehmet ÇİFTÇİ, Ömer Faruk BOZKURT