Vitamin D levels and in-hospital mortality of COVID-19

Introduction: Vitamin D deficiency may be linked to an increased susceptibility risk of COVID-19. However, the data on the link between vitamin D levels and COVID-19 related in-hospital mortality is debatable. This study investigated whether vitamin D levels are associated with intensive care unit (ICU) admission and COVID-19 related in-hospital mortality. Material and Method: We conducted a retrospective study with hospitalized COVID-19 patients between March 2020 and March 2021. 25 OH Vitamin D (Vit-D) levels

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  • Bouillon R, Marcocci C, Carmeliet G, et al. Skeletal and extra-skeletal actions of vitamin D: current evidence and outstanding questions. Endocr Rev 2019; 40: 1109-51.
  • Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-81.
  • Charoenngam N, Holick MF. Immunologic effects of vitamin D on human health and disease. Nutrients 2020; 12: 2097.
  • Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients 2015; 7: 4240-70.
  • Mercola J, Grant WB, Wagner CL. Evidence regarding vitamin D and risk of COVID-19 and its severity. Nutrients 2020; 12: 3361.
  • Grant WB, Giovannucci E. The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918–1919 influenza pandemic in the United States. Dermatoendocrinol 2009; 1: 215-9.
  • Dissanayake HA, de Silva NL, Sumanatilleke M, et al. Prognostic and therapeutic role of vitamin D in COVID-19: systematic review and meta-analysis. J Clin Endocrinol Metab 2021; dgab892.
  • Ghasemian R, Shamshirian A, Heydari K, et al. The role of vitamin D in the age of COVID‐19: A systematic review and meta‐analysis. Int J Clin Pract 2021; 75: e14675.
  • Chiodini I, Gatti D, Soranna D, et al. Vitamin D status and SARS-CoV-2 infection and COVID-19 clinical outcomes. Front Public Health 2021; 9: 736665.
  • Giustina A, Adler RA, Binkley N, et al. Controversies in vitamin D: summary statement from an international conference. J Clin Endocrinol Metab 2019; 104: 234-40.
  • Austin PC. Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Pharm Stat 2011; 10: 150-61.
  • Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-12.
  • Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract 2012; 120: c179-84.
  • Austin PC. An introduction to propensity score methods for reducing the effects of confounding in observational studies. multivar behav Res 2011; 46: 399-424.
  • Contreras-Bolívar V, García-Fontana B, García-Fontana C, Muñoz-Torres M. Vitamin D and COVID-19: where are we now? Postgrad Med 2021; 1-13
  • Liu N, Sun J, Wang X, Zhang T, Zhao M, Li H. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. Int J Infect Dis 2021; 104: 58-64.
  • Düğeroğlu H. Evaluation of 25-hydroxy vitamin D levels in COVID-19 positive patients. J Health Sci Med 2021; 4: 931-5.
  • Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet 2020; 395: 497-506.
  • Yıldırım Ö, Bayram M, Özmen RS, et al. Evaluation of hematological indices in terms of COVID-19 related mortality and ICU admission. J Health Sci Med 2021; 4: 666-9.
  • Tavakolpour S, Rakhshandehroo T, Wei EX, Rashidian M. Lymphopenia during the COVID-19 infection: What it shows and what can be learned. Immunol Lett 2020; 225: 31-2.
  • Pecina JL, Merry SP, Park JG, Thacher TD. Vitamin D status and severe COVID-19 disease outcomes in hospitalized patients. J Prim Care Community Health 2021; 12: 1-7
  • Reis BZ, Fernandes AL, Sales LP, et al. Influence of vitamin D status on hospital length of stay and prognosis in hospitalized patients with moderate to severe COVID-19: a multicenter prospective cohort study. Am J Clin Nutr 2021; 114: 598-604.
  • Weaving G, Batstone GF, Jones RG. Age and sex variation in serum albumin concentration: an observational study. Ann Clin Biochem 2016; 53: 106-11.
  • Oscanoa TJ, Amado J, Ghashut RA, Romero-Ortuno R. Relationship between serum 25-hydroxyvitamin D concentration and acute inflammatory markers in hospitalized patients with SARS-CoV-2 infection. Disaster Emerg Med J 2021; 6: 144-53.
  • Hernández JL, Nan D, Fernandez-Ayala M, et al. Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection. J Clin Endocrinol Metab 2021; 106: e1343-53.
  • Bitencourt L, Pedrosa AL, de Brito SBCS, et al. COVID-19 and Renal Diseases: An Update. Curr Drug Targets 2021; 22: 52-67.
  • Xiang HX, Fei J, Xiang Y, et al. Renal dysfunction and prognosis of COVID-19 patients: a hospital-based retrospective cohort study. BMC Infect Dis 2021; 21: 158.
  • Franca Gois PH, Wolley M, Ranganathan D, Seguro AC. Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies. Int J Environ Res Public Health 2018; 15: 1773.
  • Torres B, Alcubilla P, González-Cordón A, et al. Impact of low serum calcium at hospital admission on SARS-CoV-2 infection outcome. Int J Infect Dis 2021; 104: 164-8.
  • Alemzadeh E, Alemzadeh E, Ziaee M, Abedi A, Salehiniya H. The effect of low serum calcium level on the severity and mortality of Covid patients: A systematic review and meta‐analysis. Immun Inflamm Dis 2021; 9: 1219-28.
  • Aldasouqi S, Glassy CM, Glassy MS, Treska A, Caldwell-McMillan M, Gossain V. Asymptomatic severe hypocalcemia secondary to vitamin d deficiency in an elderly patient. Case Rep Endocrinol 2011; 2011: e830952.
  • Ünsal YA, Gül ÖÖ, Cander S, et al. Retrospective analysis of vitamin D status on ınflammatory markers and course of the disease in patients with COVID-19 infection. J Endocrinol Invest 2021; 44: 2601-7.
  • Hastie CE, Pell JP, Sattar N. Vitamin D and COVID-19 infection and mortality in UK Biobank. Eur J Nutr 2021; 60: 545-8.