Fetuin A level in advanced placental calcification at term pregnancies
Aim: Fetuin A is a multifunctional protein which is a marker of pathological calcification in several diseases. This study aimed to evaluate serum fetuin A level in term pregnancies with grade 3 placental calcification.
Material and Method: Fifty-seven pregnant women who applied obstetrics outpatient clinic for routine pregnancy follow-up at term were included in this study. The study was designed prospectively. Patients with grade 3 placental calcification (n=29) were compared to patients with non-calcified placenta (n=28) in terms of serum fetuin A levels.
Results: Maternal serum calcium levels of pregnant women with grade 3 calcified was significantly increased compared to pregnant women with non-calcified placenta. There was no significant difference between the fetuin A levels of study and control groups. The fetuin A level was not found to be correlated with maternal serum calcium level.
Conclusion: Fetuin A has been targeted as a marker for pathological calcification. The findings of the current study may support the thought that term placental calcification may be physiological rather than a pathological process.
___
- Brylka L, Jahnen-Dechent W. The role of fetuin-A in physiological and pathological mineralization. Calcified tissue international 2013; 93: 355-64.
- Mori K, Emoto M, Inaba M. Fetuin-A: a multifunctional protein. Recent patents on endocrine, metabolic & immune drug discovery 2011; 5: 124-46.
- Dautova Y, Kozlova D, Skepper JN, Epple M, Bootman MD, Proudfoot D. Fetuin-A and albumin alter cytotoxic effects of calcium phosphate nanoparticles on human vascular smooth muscle cells. PloS one 2014; 9: e97565.
- Seto J, Busse B, Gupta HS, et al. Accelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice. PloS one 2012; 7: e47338.
- Iyidir OT, Degertekin CK, Yilmaz BA, et al. Serum levels of fetuin A are increased in women with gestational diabetes mellitus. Archives of gynecology and obstetrics 2015; 291: 933-7.
- Chaemsaithong P, Romero R, Tarca AL, et al. Maternal plasma fetuin-A concentration is lower in patients who subsequently developed preterm preeclampsia than in uncomplicated pregnancy: a longitudinal study. J Matern Fetal Neonatal Med. 2015; 28: 1260-9.
- Bostom A, Pasch A, Madsen T, et al. Serum calcification propensity and fetuin-a: biomarkers of cardiovascular disease in kidney transplant recipients. Am J Nephrol 2018; 48: 21-31.
- Pan X, Wen SW, Bestman PL, Kaminga AC, Acheampong K. Fetuin-A in Metabolic syndrome: a systematic review and meta-analysis. PloS One 2020; e0229776.
- Grannum PA, Berkowitz RL, Hobbins JC. The ultrasonic changes in the maturing placenta and their relation to fetal pulmonic maturity. Am J Obstet Gynecol 1979; 133: 915-22.
- McKenna D, Tharmaratnam S, Mahsud S, Dornan J. Ultrasonic evidence of placental calcification at 36 weeks' gestation: maternal and fetal outcomes. Acta Obstet Gynecol Scand 2005; 84: 7-10.
- Mirza FG, Ghulmiyyah LM, Tamim H, Makki M, Jeha D, Nassar A. To ignore or not to ignore placental calcifications on prenatal ultrasound: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2018; 31: 797-804.
- Wallingford MC, Benson C, Chavkin NW, Chin MT, Frasch MG. Placental vascular calcification and cardiovascular health: it is time to determine how much of maternal and offspring health is written in stone. Front Physiol 2018; 9: 1044-.
- Jamal A, Moshfeghi M, Moshfeghi S, Mohammadi N, Zarean E, Jahangiri N. Is preterm placental calcification related to adverse maternal and foetal outcome? J Obstetr Gynaecol 2017; 37: 605-9.
- Chen KH, Seow KM, Chen LR. The role of preterm placental calcification on assessing risks of stillbirth. Placenta 2015; 36: 1039-44.
- Chen KH, Chen LR, Lee YH. Exploring the relationship between preterm placental calcification and adverse maternal and fetal outcome. Ultrasound Obstet Gynecol 2011; 37: 328-34.
- Poggi SH, Bostrom KI, Demer LL, Skinner HC, Koos BJ. Placental calcification: a metastatic process? Placenta 2001; 22: 591-6.
- Emmrich P. [Pathology of the placenta. X. Syncytial proliferation, calcification, cysts, pigments and metabolic disorders]. Zentralblatt fur Pathologie. 1992; 138: 77-84.
- Gomez LM, Anton L, Srinivas SK, Elovitz MA, Parry S. Effects of increased fetuin-A in human trophoblast cells and associated pregnancy outcomes. Am J Obstet Gynecol 2012; 207: 484.e1-8.
- Sun ZL, Xie QY, Guo GL, Ma K, Huang YY. Serum fetuin-A levels in patients with cardiovascular disease: a meta-analysis. BioMed Res Int 2014; 2014: 691540.
- Singh M, Sharma PK, Garg VK, Mondal SC, Singh AK, Kumar N. Role of fetuin-A in atherosclerosis associated with diabetic patients. J Pharm Pharmacol 2012; 64: 1703-8.
- Kalabay L, Cseh K, Pajor A, et al. Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes. Eur J Endocrinol 2002; 147: 243-8.
- Farhan S, Handisurya A, Todoric J, et al. Fetuin-A characteristics during and after pregnancy: result from a case control pilot study. Int J Endocrinol 2012; 2012: 896736.
- Brix JM, Stingl H, Hollerl F, Schernthaner GH, Kopp HP, Schernthaner G. Elevated fetuin-A concentrations in morbid obesity decrease after dramatic weight loss. J Clin Endocrinol Metab 2010; 95: 4877-81.
- Wang H, Sama AE. Anti-inflammatory role of fetuin-A in injury and infection. Curr Mol Med 2012; 12: 625-33.
- Oncu K, Yazgan Y, Tanoglu A, et al. Can serum fetuin-A be regarded as an inflammatory marker among patients with familial Mediterranean fever? Dig Dis Sci 2013; 58: 3212-7.
- Johnstone ED, Sawicki G, Guilbert L, Winkler-Lowen B, Cadete VJ, Morrish DW. Differential proteomic analysis of highly purified placental cytotrophoblasts in pre-eclampsia demonstrates a state of increased oxidative stress and reduced cytotrophoblast antioxidant defense. Proteomics 2011; 11: 4077-84.
- Molvarec A, Prohászka Z, Nagy B, et al. Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum alpha(2)-HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count. J Reprod Immunol 2007; 73: 172-9.
- Miller JM, Jr., Brown HL, Kissling GA, Gabert HA. The relationship of placental grade to fetal size and growth at term. Am J Perinatol 1988; 5: 19-21.
- Jung HH, Kim SW, Han H. Inflammation, mineral metabolism and progressive coronary artery calcification in patients on haemodialysis. Nephrol Dial Transplant 2006; 21: 1915-20.
- Hermans MM, Brandenburg V, Ketteler M, et al. Study on the relationship of serum fetuin-A concentration with aortic stiffness in patients on dialysis. Nephrol Dial Transplant 2006; 21: 1293-9.