Is hyperlipazemia a poor prognostic factor in patients with COVID-19 ?
Introduction: COVID-19 disease may pose a considerable health threat to healthy individuals and individuals with comorbidity. The SARS-CoV-2 virus affects the respiratory tract and may cause damage to the pancreas by binding to the ACE-2 receptor in the pancreas. In our study, we investigated the effects of hyperlipasemia on morbidity and mortality in patients diagnosed with COVID-19.
Material and Method: In this study, 2350 patients diagnosed with COVID-19 between November 2020 and December 2020 were retrospectively reviewed. Other possible causes of hyperlipasemia were excluded. Hyperlipasemia secondary to COVID-19 was detected in 338 patients. These patients were divided into two groups based on their lipase elevation rates.
Results: Hyperlipasemia was detected in 14.4% of the patients diagnosed with COVID-19, and severe hyperlipasemia (>3x) was detected in 2.3%. The mean age of the patients was 64±13.8 (18-92), of which 59.5% (201) were male. In our study, 24 patients (1%) were diagnosed with acute pancreatitis. When compared according to lipase level, a significant difference was found between the groups regarding the history of HT, CCI score, development of ARF at follow-up, development of ARDS, need for ICU hospitalization, need for intubation, length of stay in ICU, and death rates. A weak correlation was found in the correlation analysis between hyperlipasemia and ARDS development and mortality.
Conclusion: Elevated lipase levels were associated with poor prognosis and mortality in patients with COVID-19 infection.
Keywords:
SARS-CoV-2 hyperlipasemia, COVID-19, pancreatitis, viral pancreatitis,
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- Yayın Aralığı: Yılda 6 Sayı
- Başlangıç: 2018
- Yayıncı: MediHealth Academy Yayıncılık
Sayıdaki Diğer Makaleler
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Kenan ERDEM, Ipek DUMAN, Muhammet KIZMAZ, Tevfik Fikret İLGENLİ
Hüsnü BAYKAL, Ayşe Füsun ÜLGER
İhsan KAPLAN, Canan CAN, Halil KÖMEK, Ferat KEPENEK, Hikmet SOYLU, Erkan ERDUR, Nurşin AGÜLOĞLU, Cihan GÜNDOĞAN
Selda ÇELİK DÜLGER, Mehmet ÇITIRIK, Esra BAHADİR CAMGOZ, Mehmet Yasin TEKE
Ercan TÜRKMEN, Mahmut ALTINDAL, Ferah TARAN, Tuba KURUOĞLU, Aydın DEVECİ, Melih AKPUNAR, Seyyid Bilal AÇIKGÖZ, Nurhan KÖKSAL
Ahmet Hikmet ŞAHİN, Murat Sabri YILMAZ
Hicran ŞİRİNOĞLU, Savaş ÖZDEMİR, Oya GÖKÇER, Simten GENÇ, Cagdas Nurettin EMEKLİOGLU, Enis ÖZKAYA